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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
26
hits in this display
Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: 0.110nM
Assay Description:
In vitro relaxation of carbachol pre-contracted rat oesophageal TMM.
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Target
5-hydroxytryptamine receptor 3A
(Homo sapiens (Human))
TBA
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: 0.182nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 3 receptor by displacement of [3H]-BRL 43694 from NG-108-15 cell membranes
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: 0.200nM
Assay Description:
Binding affinity to 5-hydroxytryptamine 3 receptor in rat entorhinal cortex using [3H]-BRL 43694 as radioligand
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: 0.200nM
Assay Description:
Antagonistic activity against Serotonin 5-hydroxytryptamine 3 receptor in isolated rabbit vagus nerve (RVN)
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.200nM
Assay Description:
Binding affinity against 5-hydroxytryptamine 3 receptor using [3H]BRL-43694 as radioligand in rat posterior cortex
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.200nM
Assay Description:
Binding affinity at 5-hydroxytryptamine 3 receptor in rat entorhinal cortex by [3H]-BRL-43694 displacement.
More data for this Ligand-Target Pair
Target Info
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.200nM
Assay Description:
Inhibition of [3H]GR-65630 binding to rat cortical membrane serotonin 5-hydroxytryptamine 3 receptor
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Target
5-hydroxytryptamine receptor 3A
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: 0.230nM
Assay Description:
Compound was evaluated in vivo for the antagonistic activity towards 5-hydroxytryptamine 3 receptor
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.25nM
Assay Description:
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]quipazine
Checked by Author
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
TBA
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.251nM
Assay Description:
Binding affinity to 5-hydroxytryptamine 3 receptor was determined in rat cerebro cortical membranes using [3H]quipazine.
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Target
5-hydroxytryptamine receptor 4
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
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Affinity Data
Ki: 131nM
Assay Description:
Binding affinity at 5-hydroxytryptamine 4 receptor in rat striatum by [3H]GR-113808 displacement.
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Target
5-hydroxytryptamine receptor 4
(GUINEA PIG)
Dainippon Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Copy SMILES
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Affinity Data
Ki: 383nM
Assay Description:
Inhibition of [3H]GR-113808 binding to guinea pig striatum 5-hydroxytryptamine 4 receptor
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Target
5-hydroxytryptamine receptor 4
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 383nM
Assay Description:
Binding affinity against 5-hydroxytryptamine 4 receptor using [3H]GR-113808 as radioligand in rat striatum
More data for this Ligand-Target Pair
Target Info
PDB
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UniProtKB/SwissProt
GoogleScholar
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CHEMBL
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Target
5-hydroxytryptamine receptor 4
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 383nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand
More data for this Ligand-Target Pair
Target Info
PDB
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Article
PubMed
Copy BDB DOI
Target
5-hydroxytryptamine receptor 4
(GUINEA PIG)
Dainippon Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 437nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 4 receptor by displacement of [3H]GR-113808 from guinea pig brain striatum.
More data for this Ligand-Target Pair
Target Info
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Target
5-hydroxytryptamine receptor 4
(GUINEA PIG)
Dainippon Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 501nM
More data for this Ligand-Target Pair
Target Info
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Article
PubMed
Copy BDB DOI
Target
5-hydroxytryptamine receptor 4
(GUINEA PIG)
Dainippon Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 501nM
More data for this Ligand-Target Pair
Target Info
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
Dainippon Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Copy SMILES
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Affinity of compound towards d Dopamine receptor D2 in rat striatum using [3H]spiperone as radioligand
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 4
(GUINEA PIG)
Dainippon Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.00E+3nM
More data for this Ligand-Target Pair
Target Info
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PubMed
Copy BDB DOI
Target
5-hydroxytryptamine receptor 4
(GUINEA PIG)
Dainippon Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.00E+3nM
More data for this Ligand-Target Pair
Target Info
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Ligand Info
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CHEMBL
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Article
PubMed
Copy BDB DOI
Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
Dainippon Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+3nM
Assay Description:
Binding affinity against Dopamine receptor D2 using [3H]spiperone as radioligand in rat striatum
More data for this Ligand-Target Pair
Target Info
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Target
5-hydroxytryptamine receptor 3A
(Homo sapiens (Human))
TBA
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Copy SMILES
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Affinity Data
Ki: 5.01E+3nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 3 receptor by displacement of [3H](R)-zacopride from ondansetron-treated NG-108-15 cell membranes
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 4
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 63nM
Assay Description:
5-hydroxytryptamine 4 receptor agonist activity in the rat esophageal muscularis mucosae
More data for this Ligand-Target Pair
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Target
5-hydroxytryptamine receptor 4
(GUINEA PIG)
Dainippon Pharmaceutical
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 77nM
Assay Description:
5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...
More data for this Ligand-Target Pair
Target Info
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Target
5-hydroxytryptamine receptor 4
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 56nM
Assay Description:
In vitro relaxation of carbachol pre-contracted rat oesophageal TMM.
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
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CHEMBL
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Copy BDB DOI
Target
5-hydroxytryptamine receptor 4
(RAT)
TBA
Curated by
ChEMBL
Ligand
BDBM50056419
(4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 203nM
Assay Description:
Compound was evaluated for the agonistic activity towards 5-hydroxytryptamine 4 receptor using the rat tunica muscularis mucosae (TMM) esophagus stri...
More data for this Ligand-Target Pair
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