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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
17
hits in this display
Target
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human))
Harvard Medical School
Curated by
ChEMBL
Ligand
BDBM50042034
((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)
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Affinity Data
IC50: 2.90nM
Assay Description:
Inhibition of full length recombinant human His-tagged MEK1 expressed in baculovirus expression system after 1 hr by TR-FRET based LanthaScreen assay
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Target
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human))
Dana-Farber Cancer Institute
Curated by
ChEMBL
Ligand
BDBM50042034
((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)
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Affinity Data
IC50: 5.60nM
Assay Description:
Inhibition of TAK1 (unknown origin) by LanthaScreen assay
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Target
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human))
Dana-Farber Cancer Institute
Curated by
ChEMBL
Ligand
BDBM50042034
((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)
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Affinity Data
IC50: 5.60nM
Assay Description:
Inhibition of full length recombinant human GST-tagged TAK1 expressed in baculovirus expression system after 1 hr by TR-FRET based LanthaScreen assay
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Target
Mitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
(Homo sapiens (Human))
Myrexis
Curated by
ChEMBL
Ligand
BDBM50042034
((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)
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Affinity Data
IC50: 8nM
Assay Description:
Competitive inhibition of recombinant TAK1-TAB1 assessed as [33P]gamma-ATP incorporation into substrate histone H1 peptide by filter plate assay
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Target
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human))
Dana-Farber Cancer Institute
Curated by
ChEMBL
Ligand
BDBM50042034
((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)
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Affinity Data
IC50: 8.10nM
Assay Description:
Inhibition of TAK1 (unknown origin) expressed in sf9 cells assessed as 32P level incorporation into myelin basic protein incubated for 5 mins at 30 d...
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Target
Nuclear receptor subfamily 2 group C member 2/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
(Homo sapiens (Human))
China Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50042034
((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)
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Affinity Data
IC50: 9nM
Assay Description:
Inhibition of Tak1/Tab1 (unknown origin) assessed as inhibition of Tak1 kinase activity preincubated for 30 mins followed by addition of MBP protein ...
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Target
Mitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
(Homo sapiens (Human))
Myrexis
Curated by
ChEMBL
Ligand
BDBM50042034
((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)
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Affinity Data
IC50: 9nM
Assay Description:
Inhibition of full length TAK1/TAB1 (unknown origin) using biotin-MKK6 as substrate by AlphaScreen assay
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Target
Mitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
(Homo sapiens (Human))
Myrexis
Curated by
ChEMBL
Ligand
BDBM50042034
((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)
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Affinity Data
IC50: 9nM
Assay Description:
Inhibition of full length TAK1/TAB1 (unknown origin) using biotin-MKK6 as substrate by AlphaScreen assay
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Target
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human))
Dana-Farber Cancer Institute
Curated by
ChEMBL
Ligand
BDBM50042034
((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)
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Affinity Data
IC50: 9nM
Assay Description:
Inhibition of full length TAK1 (unknown origin) fused with TAB1 using biotin-MKK6 as substrate by AlphaScreen assay
More data for this Ligand-Target Pair
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Target
Phospholipase A-2-activating protein
(Homo sapiens (Human))
University of Pittsburgh
Curated by
ChEMBL
Ligand
BDBM50042034
((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)
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Affinity Data
IC50: 11nM
Assay Description:
Inhibition of TNFalpha-PLAP (unknown origin)
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Target
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human))
Dana-Farber Cancer Institute
Curated by
ChEMBL
Ligand
BDBM50042034
((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)
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Affinity Data
IC50: 11nM
Assay Description:
Inhibition of TAK1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Mitogen-activated protein kinase kinase kinase 7
(Homo sapiens (Human))
Dana-Farber Cancer Institute
Curated by
ChEMBL
Ligand
BDBM50042034
((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)
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Affinity Data
IC50: 80nM
Assay Description:
Inhibition of TAK1 (unknown origin) using unphosphorylated GST-tagged MAP2K7 substrate protein assessed as phosphorylation by ELISA
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Target
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human))
Harvard Medical School
Curated by
ChEMBL
Ligand
BDBM50042034
((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)
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Affinity Data
IC50: 80nM
Assay Description:
Inhibition of MAP2K1 (unknown origin) using unphosphorylated GST-tagged ERK2 substrate protein assessed as phosphorylation by ELISA
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Target
Mitogen-activated protein kinase 1
(Homo sapiens (Human))
Harvard Medical School
Curated by
ChEMBL
Ligand
BDBM50042034
((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)
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Affinity Data
IC50: 738nM
Assay Description:
Inhibition of full length recombinant human GST-tagged ERK2 expressed in Escherichia coli using Ser/Thr 03 as substrate after 1 hr by Z'-Lyte assay
More data for this Ligand-Target Pair
Target Info
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Target
Dual specificity mitogen-activated protein kinase kinase 7
(Homo sapiens (Human))
Osaka Prefecture University
Curated by
ChEMBL
Ligand
BDBM50042034
((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)
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Affinity Data
IC50: 1.30E+3nM
Assay Description:
Inhibition of MAP2K7 (unknown origin) using unphosphorylated GST-tagged JNK1 substrate protein assessed as phosphorylation by ELISA
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Target
Mitogen-activated protein kinase 1
(Homo sapiens (Human))
Harvard Medical School
Curated by
ChEMBL
Ligand
BDBM50042034
((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)
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Affinity Data
IC50: 6.80E+3nM
Assay Description:
Inhibition of ERK2 (unknown origin) using FITC-labeled substrate peptide assessed as phosphorylation
More data for this Ligand-Target Pair
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Target
BMP-2-inducible protein kinase
(Homo sapiens (Human))
Centro De Investigaciones Biol�Gicas Margarita Salas (Csic)
Curated by
ChEMBL
Ligand
BDBM50042034
((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)
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Affinity Data
Kd: 3.80nM
Assay Description:
Binding affinity to BIKE (unknown origin) assessed as dissociation constant
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