Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetActivin receptor type-1(Mus musculus)
Massachusetts Institute Of Technology

Curated by ChEMBL

LigandBDBM50056684(CHEMBL3341941 | US10688093, Compound 382_0087_7249...)Copy SMILESCopy InChI

Affinity DataIC50:  20nMAssay Description:Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Massachusetts Institute Of Technology

Curated by ChEMBL

LigandBDBM50056684(CHEMBL3341941 | US10688093, Compound 382_0087_7249...)Copy SMILESCopy InChI

Affinity DataIC50:  580nMAssay Description:Inhibition of TGFbeta1-induced TGFbeta type 1 ALK5 in HEK293T cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Pathways Neuro Pharma

US Patent

LigandBDBM50056684(CHEMBL3341941 | US10688093, Compound 382_0087_7249...)Copy SMILESCopy InChI

Affinity DataIC50:  1.73E+3nMAssay Description:The assay procedure determines the IC50 of each potential FYN kinase inhibitor by measuring the enzyme catalyzed ATP-dependent phosphorylation of the...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails US Patent
Copy BDB DOI