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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
7
hits in this display
Target
Leucine-rich repeat serine/threonine-protein kinase 2
(Homo sapiens (Human))
Califia Bio
Curated by
ChEMBL
Ligand
BDBM50441571
(CHEMBL2436982 | US10485800, Example 18 | US9814704...)
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Affinity Data
IC50: 5nM
Assay Description:
Inhibition of human wild type LRRK2 by qPCR analysis
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Mitogen-activated protein kinase kinase kinase 11
(Homo sapiens (Human))
Califia Bio
Curated by
ChEMBL
Ligand
BDBM50441571
(CHEMBL2436982 | US10485800, Example 18 | US9814704...)
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Affinity Data
IC50: 7nM
Assay Description:
Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATP
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Mitogen-activated protein kinase kinase kinase 11
(Homo sapiens (Human))
Califia Bio
Curated by
ChEMBL
Ligand
BDBM50441571
(CHEMBL2436982 | US10485800, Example 18 | US9814704...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <100nM
Assay Description:
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Mitogen-activated protein kinase kinase kinase 11
(Homo sapiens (Human))
Califia Bio
Curated by
ChEMBL
Ligand
BDBM50441571
(CHEMBL2436982 | US10485800, Example 18 | US9814704...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <100nM
Assay Description:
200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Mitogen-activated protein kinase kinase kinase 11
(Mus musculus)
Califia Bio
Curated by
ChEMBL
Ligand
BDBM50441571
(CHEMBL2436982 | US10485800, Example 18 | US9814704...)
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Affinity Data
IC50: 120nM
Assay Description:
Inhibition of MLK3 in mouse BV2 cells assessed as inhibition of LPS-induced TNFalpha release after 8 hrs by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Califia Bio
Curated by
ChEMBL
Ligand
BDBM50441571
(CHEMBL2436982 | US10485800, Example 18 | US9814704...)
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Affinity Data
IC50: >3.00E+4nM
Assay Description:
Inhibition of CYP2D6 in human liver microsomes assessed as inhibition of diclofenac metabolism by HPLC/MS analysis
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Califia Bio
Curated by
ChEMBL
Ligand
BDBM50441571
(CHEMBL2436982 | US10485800, Example 18 | US9814704...)
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Affinity Data
IC50: >3.00E+4nM
Assay Description:
Inhibition of CYP2C9 in human liver microsomes assessed as inhibition of midazolam metabolism by HPLC/MS analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI