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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM356235(BDBM50441572 | US10485800, Example 1 | US9814704, ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM356235(BDBM50441572 | US10485800, Example 1 | US9814704, ...)
Affinity DataIC50:  35nMAssay Description:Inhibition of human wild type LRRK2 by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM356235(BDBM50441572 | US10485800, Example 1 | US9814704, ...)
Affinity DataIC50: <100nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM356235(BDBM50441572 | US10485800, Example 1 | US9814704, ...)
Affinity DataIC50:  550nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM354724(US9814704, Example 1)
Affinity DataIC50:  550nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 11(Mus musculus)
Califia Bio

Curated by ChEMBL
LigandPNGBDBM356235(BDBM50441572 | US10485800, Example 1 | US9814704, ...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of MLK3 in mouse BV2 cells assessed as inhibition of LPS-induced TNFalpha release after 8 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM356235(BDBM50441572 | US10485800, Example 1 | US9814704, ...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as inhibition of diclofenac metabolism by HPLC/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Califia Bio

Curated by ChEMBL
LigandPNGBDBM356235(BDBM50441572 | US10485800, Example 1 | US9814704, ...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as inhibition of midazolam metabolism by HPLC/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed