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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
hits in this display
Target
Bromodomain-containing protein 4
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM380631
(6-(4-chlorophenyl)-2-cyclopropyl-1-isopropyl-5-(8-...)
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Affinity Data
IC50: 41nM
Assay Description:
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Bromodomain-containing protein 3
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM380631
(6-(4-chlorophenyl)-2-cyclopropyl-1-isopropyl-5-(8-...)
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Copy InChI
Affinity Data
IC50: 75nM
Assay Description:
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Bromodomain-containing protein 2
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM380631
(6-(4-chlorophenyl)-2-cyclopropyl-1-isopropyl-5-(8-...)
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Copy InChI
Affinity Data
IC50: 100nM
Assay Description:
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
CREB-binding protein
(Homo sapiens (Human))
Novartis
US Patent
Ligand
BDBM380631
(6-(4-chlorophenyl)-2-cyclopropyl-1-isopropyl-5-(8-...)
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Copy InChI
Affinity Data
IC50: >3.70E+4nM
Assay Description:
In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI