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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
hits in this display
Target
Leukotriene C4 synthase
(Homo sapiens (Human))
Orexo
Curated by
ChEMBL
Ligand
BDBM50519565
(CHEMBL4441362)
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Affinity Data
IC50: 0.758nM
Assay Description:
Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
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Target
Leukotriene C4 synthase
(Homo sapiens (Human))
Orexo
Curated by
ChEMBL
Ligand
BDBM223232
(2-(5-((Cyclopropylmethyl)(4-fluoronaphthalen-1-yl)...)
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Affinity Data
IC50: 18nM
Assay Description:
In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Leukotriene C4 synthase
(Homo sapiens (Human))
Orexo
Curated by
ChEMBL
Ligand
BDBM223232
(2-(5-((Cyclopropylmethyl)(4-fluoronaphthalen-1-yl)...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 18nM
pH: 7.8
Assay Description:
In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Leukotriene C4 synthase
(Homo sapiens (Human))
Orexo
Curated by
ChEMBL
Ligand
BDBM50519565
(CHEMBL4441362)
Copy SMILES
Copy InChI
Affinity Data
IC50: <25nM
Assay Description:
Inhibition of recombinant human N-terminal His6-tagged LTC4S expressed in in Pichia pastoris X33 assessed as inhibition of EXC4 formation using EXA4 ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Leukotriene C4 synthase
(Homo sapiens (Human))
Orexo
Curated by
ChEMBL
Ligand
BDBM50519565
(CHEMBL4441362)
Copy SMILES
Copy InChI
Affinity Data
IC50: 27nM
Assay Description:
Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI