Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 16 hits in this display   

TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Universidad De Oviedo-Principado De Asturias

Curated by ChEMBL

LigandBDBM50281297(CHEMBL4170114)Copy SMILESCopy InChI

Affinity DataIC50:  8nMAssay Description:Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
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TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Universidad De Oviedo-Principado De Asturias

Curated by ChEMBL

LigandBDBM50281297(CHEMBL4170114)Copy SMILESCopy InChI

Affinity DataIC50:  8nMAssay Description:Inhibition of G9a (unknown origin) using biotinylated histone monomethyl-H3K9 peptide by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

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TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Universidad De Oviedo-Principado De Asturias

Curated by ChEMBL

LigandBDBM50281297(CHEMBL4170114)Copy SMILESCopy InChI

Affinity DataIC50:  8nMAssay Description:Inhibition of human G9a enzyme using histone monomethyl-H3K9 peptide as substrate incubated for 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Universidad De Oviedo-Principado De Asturias

Curated by ChEMBL

LigandBDBM50281297(CHEMBL4170114)Copy SMILESCopy InChI

Affinity DataIC50:  8nMAssay Description:Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Universidad De Oviedo-Principado De Asturias

Curated by ChEMBL

LigandBDBM50281297(CHEMBL4170114)Copy SMILESCopy InChI

Affinity DataIC50:  16nMAssay Description:Inhibition of G9a (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

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In DepthDetails ArticlePubMed
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TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Wuxi Apptec (Tianjin) Co.

Curated by ChEMBL

LigandBDBM50281297(CHEMBL4170114)Copy SMILESCopy InChI

Affinity DataIC50:  382nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

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TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Wuxi Apptec (Tianjin) Co.

Curated by ChEMBL

LigandBDBM50281297(CHEMBL4170114)Copy SMILESCopy InChI

Affinity DataIC50:  382nMAssay Description:Inhibition of DNMT1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Wuxi Apptec (Tianjin) Co.

Curated by ChEMBL

LigandBDBM50281297(CHEMBL4170114)Copy SMILESCopy InChI

Affinity DataIC50:  382nMAssay Description:Inhibition of human DNMT1 enzyme using polydeoxy-inosine polydeoxy-cytosine DNA as substrate incubated for 15 mins in presence of SAM by TR-FRET assa...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Wuxi Apptec (Tianjin) Co.

Curated by ChEMBL

LigandBDBM50281297(CHEMBL4170114)Copy SMILESCopy InChI

Affinity DataIC50:  382nMAssay Description:Inhibition of DNMT1 (unknown origin) using biotinylated histone monomethyl-H3K9 peptide by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetDNA (cytosine-5)-methyltransferase 1(Homo sapiens (Human))
Wuxi Apptec (Tianjin) Co.

Curated by ChEMBL

LigandBDBM50281297(CHEMBL4170114)Copy SMILESCopy InChI

Affinity DataIC50:  382nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Navarra

Curated by ChEMBL

LigandBDBM50281297(CHEMBL4170114)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of full length human N-terminal GST-tagged HDAC6 using fluorogenic acetylated peptide as substrate incubated for 30 mins by fluorescence p...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

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TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
University Of Navarra

Curated by ChEMBL

LigandBDBM50281297(CHEMBL4170114)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of full length human C-terminal His-tagged HDAC3/human N-terminal GST-agged NCOR2 using fluorogenic acetylated peptide as substrate incuba...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaantibodypediaGoogleScholar

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TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Navarra

Curated by ChEMBL

LigandBDBM50281297(CHEMBL4170114)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of full length human C-terminal His-tagged/C-terminal Flag-tagged HDAC1 using fluorogenic acetylated peptide as substrate incubated for 30...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetHistone deacetylase 2(Homo sapiens (Human))
University Of Navarra

Curated by ChEMBL

LigandBDBM50281297(CHEMBL4170114)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of full length human C-terminal His-tagged HDAC2 using fluorogenic acetylated peptide as substrate incubated for 30 mins by fluorescence p...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Wuxi Apptec (Tianjin) Co.

Curated by ChEMBL

LigandBDBM50281297(CHEMBL4170114)Copy SMILESCopy InChI

Affinity DataIC50: <1.00E+5nMAssay Description:Inhibition of Tracer Red binding to human ERG in membranes after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Wuxi Apptec (Tianjin) Co.

Curated by ChEMBL

LigandBDBM50281297(CHEMBL4170114)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Tracer Red binding to human ERG in membranes after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI