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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
8
hits in this display
Target
Coagulation factor VII
(Homo sapiens (Human))
F. Hoffmann-La Roche
Ligand
BDBM13592
(2-{2-[(4-carbamimidoylphenyl)carbamoyl]-6-methoxyp...)
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Affinity Data
Ki: 10nM ΔG°: -45.2kJ/mole
pH: 7.8 T: 2°C
Assay Description:
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
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Target
Coagulation factor X
(Homo sapiens (Human))
F. Hoffmann-La Roche
Ligand
BDBM13592
(2-{2-[(4-carbamimidoylphenyl)carbamoyl]-6-methoxyp...)
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Affinity Data
Ki: 150nM
Assay Description:
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Serine protease 1
(Bos taurus (bovine))
F. Hoffmann-La Roche
Ligand
BDBM13592
(2-{2-[(4-carbamimidoylphenyl)carbamoyl]-6-methoxyp...)
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Affinity Data
Ki: 240nM
Assay Description:
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
MMDB
Copy BDB DOI
Target
Prothrombin
(Homo sapiens (Human))
F. Hoffmann-La Roche
Ligand
BDBM13592
(2-{2-[(4-carbamimidoylphenyl)carbamoyl]-6-methoxyp...)
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Affinity Data
Ki: 4.30E+3nM ΔG°: -30.3kJ/mole
pH: 7.8 T: 2°C
Assay Description:
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor VII
(Homo sapiens (Human))
F. Hoffmann-La Roche
Ligand
BDBM13592
(2-{2-[(4-carbamimidoylphenyl)carbamoyl]-6-methoxyp...)
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Affinity Data
IC50: 5nM
Assay Description:
Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 mins
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
PDB
3D Structure (crystal)
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
F. Hoffmann-La Roche
Ligand
BDBM13592
(2-{2-[(4-carbamimidoylphenyl)carbamoyl]-6-methoxyp...)
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Copy InChI
Affinity Data
IC50: 35nM
Assay Description:
Inhibition of human F10a using S-2222 as substrate after 3 mins
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor XI
(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development
Curated by
ChEMBL
Ligand
BDBM13592
(2-{2-[(4-carbamimidoylphenyl)carbamoyl]-6-methoxyp...)
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Affinity Data
IC50: 3.90E+3nM
Assay Description:
Inhibition of human F11a using S-2366 as substrate after 3 mins
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Tissue-type plasminogen activator
(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development
Curated by
ChEMBL
Ligand
BDBM13592
(2-{2-[(4-carbamimidoylphenyl)carbamoyl]-6-methoxyp...)
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Affinity Data
IC50: >3.30E+4nM
Assay Description:
Inhibition of human tissue plasminogen activator using spectrozyme tissue plasminogen activator as substrate after 3 mins
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI