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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetCathepsin K(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM19745(2-Cyano-pyrimidine, 17j | 2-cyano-4-[(2,2-dimethyl...)
Affinity DataIC50:  0.0310nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM19745(2-Cyano-pyrimidine, 17j | 2-cyano-4-[(2,2-dimethyl...)
Affinity DataIC50:  0.580nMpH: 5.5 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM19745(2-Cyano-pyrimidine, 17j | 2-cyano-4-[(2,2-dimethyl...)
Affinity DataIC50:  2.60nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed