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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 12 hits in this display   

TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50244066(CHEMBL4083365)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50244066(CHEMBL4083365)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50244066(CHEMBL4083365)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50244066(CHEMBL4083365)
Affinity DataEC50:  210nMAssay Description:Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50244066(CHEMBL4083365)
Affinity DataEC50:  110nMAssay Description:Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50244066(CHEMBL4083365)
Affinity DataEC50:  330nMAssay Description:Agonist activity at GPR40 in mouse STC1 cells assessed as induction of GLP-1 secretion measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50244066(CHEMBL4083365)
Affinity DataEC50:  110nMAssay Description:Positive allosteric modulation of human GPR40 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50244066(CHEMBL4083365)
Affinity DataEC50:  4.40E+3nMAssay Description:Transactivation of PPARgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50244066(CHEMBL4083365)
Affinity DataEC50:  4.40E+3nMAssay Description:Transactivation of human Gal4 fused PPARgamma-LBD expressed in HEK293 cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50244066(CHEMBL4083365)
Affinity DataEC50:  210nMAssay Description:Agonist activity at human GPR40 transfected in HEK293 cells assessed as induction of cAMP accumulation incubated for 30 to 45 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50244066(CHEMBL4083365)
Affinity DataEC50:  4.40E+3nMAssay Description:Agonist activity at PPARgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50244066(CHEMBL4083365)
Affinity DataEC50:  54nMAssay Description:Agonist activity at GPR40 in mouse STC1 cells assessed as induction of GLP-1 secretion measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed