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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290835((3,4-Dimethoxy-phenyl)-(6,7-dimethoxy-quinazolin-4...)
Affinity DataIC50:  350nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylation.More data for this Ligand-Target Pair
In DepthDetails Article
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Rajiv Gandhi Proudyogiki Vishwavidyalaya

Curated by ChEMBL
LigandPNGBDBM50290835((3,4-Dimethoxy-phenyl)-(6,7-dimethoxy-quinazolin-4...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human recombinant GST-fused CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290835((3,4-Dimethoxy-phenyl)-(6,7-dimethoxy-quinazolin-4...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of epidermal growth factor receptor (EGF-R) autophosphorylation in A431 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50290835((3,4-Dimethoxy-phenyl)-(6,7-dimethoxy-quinazolin-4...)
Affinity DataIC50:  3.79E+3nMAssay Description:Inhibition of human BCRP expressed in MDCK2 cells assessed as pheophorbide A accumulation treated 30 mins before pheophorbide A addition measured up ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290835((3,4-Dimethoxy-phenyl)-(6,7-dimethoxy-quinazolin-4...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.More data for this Ligand-Target Pair
In DepthDetails Article
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50290835((3,4-Dimethoxy-phenyl)-(6,7-dimethoxy-quinazolin-4...)
Affinity DataIC50:  7.38E+3nMAssay Description:Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation treated 30 mins before Hoechst 33342 addition measured up to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Rajiv Gandhi Proudyogiki Vishwavidyalaya

Curated by ChEMBL
LigandPNGBDBM50290835((3,4-Dimethoxy-phenyl)-(6,7-dimethoxy-quinazolin-4...)
Affinity DataIC50: >1.00E+4nMAssay Description:inhibition of human recombinant CDK5/p25 using histone H1 as substrate by scintillation counting in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290835((3,4-Dimethoxy-phenyl)-(6,7-dimethoxy-quinazolin-4...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of p56 Lck tyrosine kinase in Jurkat cells where p56lck autophosphorylation is inhibited.More data for this Ligand-Target Pair
In DepthDetails Article