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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
11
hits in this display
Target
Beta-secretase 1
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50303748
((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
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Affinity Data
IC50: 70nM
Assay Description:
Inhibition of human BACE1 by FRET based peptide cleavage assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Beta-secretase 1
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50303748
((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 160nM
Assay Description:
Inhibition of human BACE1 by FRET based peptide cleavage assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Beta-secretase 2
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50303748
((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 230nM
Assay Description:
Inhibition of human BACE2 by FRET based peptide cleavage assay
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Beta-secretase 1
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50303748
((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 280nM
Assay Description:
Inhibition of human BACE1
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Beta-secretase 2
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50303748
((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 680nM
Assay Description:
Inhibition of human BACE2 by FRET based peptide cleavage assay
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cathepsin D
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50303748
((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
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Affinity Data
IC50: 1.34E+4nM
Assay Description:
Inhibition of human cathepsin D by FRET based peptide cleavage assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cathepsin D
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50303748
((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.53E+4nM
Assay Description:
Inhibition of human cathepsin D by FRET based peptide cleavage assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Renin
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50303748
((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
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Affinity Data
IC50: 5.33E+4nM
Assay Description:
Inhibition of human recombinant renin by FRET based peptide cleavage assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Beta-secretase 1
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50303748
((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 70nM
Assay Description:
Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Beta-secretase 1
(Homo sapiens (Human))
Wyeth Research
Curated by
ChEMBL
Ligand
BDBM50303748
((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 44nM
Assay Description:
Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Methylosome protein 50/Protein arginine N-methyltransferase 5
(Homo sapiens (Human))
Merck
Curated by
ChEMBL
Ligand
BDBM50303748
((S)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
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Affinity Data
EC50: 3.10E+3nM
Assay Description:
Inhibition of recombinant Avi-tagged PRMT5 (2 to 637)/ His-tagged MEP50 (2 to 342) (unknown origin) expressed in baculovirus infected Sf21 cells usin...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI