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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303760((R)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
Affinity DataIC50:  2.08E+4nMAssay Description:Inhibition of human cathepsin D by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50303760((R)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
Affinity DataEC50:  4.60E+3nMAssay Description:Inhibition of PRMT5 in human MCF7 cells assessed as reduction in symmetrically dimethylated nuclear protein level incubated for 3 days by Alexafluor-...More data for this Ligand-Target Pair
LigandPNGBDBM50303760((R)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
Affinity DataEC50:  16nMAssay Description:Inhibition of recombinant Avi-tagged PRMT5 (2 to 637)/ His-tagged MEP50 (2 to 342) (unknown origin) expressed in baculovirus infected Sf21 cells usin...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303760((R)-5-Adamantan-1-yl-2-amino-5-(4-methoxy-phenyl)-...)
Affinity DataEC50:  1.20E+3nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed