Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 11 hits in this display   

TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent

LigandBDBM234497(US9353089, 117)Copy SMILESCopy InChI

Affinity DataIC50:  3.96nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADDrugBankGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetPlasmepsin II(Plasmodium falciparum)
Saint Louis University

US Patent

LigandBDBM234497(US9353089, 117)Copy SMILESCopy InChI

Affinity DataIC50:  4nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADDrugBankGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetPlasmepsin IV [1-448](Plasmodium falciparum)
Saint Louis University

US Patent

LigandBDBM234497(US9353089, 117)Copy SMILESCopy InChI

Affinity DataIC50:  15nMpH: 4.5 T: 2°CAssay Description:Plasmepsin-2 (PM-2; Plm II) and Plasmepsin (PM-4; Plm IV) expression and purification was performed following the published protocols (Istvan E S and...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetCytochrome P450 3A4(Homo sapiens (Human))
Saint Louis University

US Patent

LigandBDBM234497(US9353089, 117)Copy SMILESCopy InChI

Affinity DataIC50:  449nMT: 2°CAssay Description:The cytochrome P450 inhibitory potentials of compounds for human recombinant CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A were determined using Vivid C...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetCathepsin E(Homo sapiens (Human))
Saint Louis University

US Patent

LigandBDBM234497(US9353089, 117)Copy SMILESCopy InChI

Affinity DataIC50:  1.19E+3nMpH: 4.0 T: 2°CAssay Description:The recombinant human BACE1, Cathepsin D, and Cathepsin E enzymes were purchased from R&D Systems (catalog numbers are 931-AS, 1014AS and 1294AS, res...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetCytochrome P450 2C19(Homo sapiens (Human))
Saint Louis University

US Patent

LigandBDBM234497(US9353089, 117)Copy SMILESCopy InChI

Affinity DataIC50:  5.48E+3nMT: 2°CAssay Description:The cytochrome P450 inhibitory potentials of compounds for human recombinant CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A were determined using Vivid C...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetCytochrome P450 2D6(Homo sapiens (Human))
Saint Louis University

US Patent

LigandBDBM234497(US9353089, 117)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:The cytochrome P450 inhibitory potentials of compounds for human recombinant CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A were determined using Vivid C...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetCathepsin D(Homo sapiens (Human))
Saint Louis University

US Patent

LigandBDBM234497(US9353089, 117)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMpH: 4.0 T: 2°CAssay Description:The recombinant human BACE1, Cathepsin D, and Cathepsin E enzymes were purchased from R&D Systems (catalog numbers are 931-AS, 1014AS and 1294AS, res...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetCytochrome P450 1A2(Homo sapiens (Human))
Saint Louis University

US Patent

LigandBDBM234497(US9353089, 117)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:The cytochrome P450 inhibitory potentials of compounds for human recombinant CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A were determined using Vivid C...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetBeta-secretase 1(Homo sapiens (Human))
Saint Louis University

US Patent

LigandBDBM234497(US9353089, 117)Copy SMILESCopy InChI

Affinity DataIC50:  1.20E+4nMpH: 4.0 T: 2°CAssay Description:The recombinant human BACE1, Cathepsin D, and Cathepsin E enzymes were purchased from R&D Systems (catalog numbers are 931-AS, 1014AS and 1294AS, res...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI

TargetBeta-secretase 1(Homo sapiens (Human))
Saint Louis University

US Patent

LigandBDBM234497(US9353089, 117)Copy SMILESCopy InChI

Affinity DataIC50:  1.20E+4nMpH: 4.0 T: 2°CAssay Description:The recombinant human BACE1, Cathepsin D, and Cathepsin E enzymes were purchased from R&D Systems (catalog numbers are 931-AS, 1014AS and 1294AS, res...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails US Patent
Copy BDB DOI