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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
15
hits in this display
Target
72 kDa type IV collagenase
(Homo sapiens (Human))
Pomona College
Curated by
ChEMBL
Ligand
BDBM11331
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)
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Affinity Data
Ki: 18nM
Assay Description:
Inhibition of MMP2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
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Article
PubMed
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Target
72 kDa type IV collagenase
(Homo sapiens (Human))
Pomona College
Curated by
ChEMBL
Ligand
BDBM11331
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)
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Affinity Data
Ki: 18nM
Assay Description:
Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
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In Depth
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Article
PubMed
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Target
Collagenase ColG
(Clostridium histolyticum)
Universita Degli Studi
Ligand
BDBM11331
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)
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Affinity Data
Ki: 27nM
Assay Description:
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
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Target
Neutrophil collagenase
(Homo sapiens (Human))
Universita Degli Studi
Ligand
BDBM11331
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)
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Affinity Data
Ki: 31nM
Assay Description:
Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
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Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Pomona College
Curated by
ChEMBL
Ligand
BDBM11331
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)
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Affinity Data
Ki: 42nM
Assay Description:
Inhibition of MMP9
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Matrix metalloproteinase-9
(Homo sapiens (Human))
Pomona College
Curated by
ChEMBL
Ligand
BDBM11331
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 42nM
Assay Description:
Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Interstitial collagenase
(Homo sapiens (Human))
Universita Degli Studi
Ligand
BDBM11331
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)
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Affinity Data
Ki: 60nM
Assay Description:
Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
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Target
Stromelysin-1
(Homo sapiens (Human))
Novartis Pharmaceuticals
Ligand
BDBM11331
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)
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Affinity Data
Ki: 70nM ΔG°: -42.5kJ/mole
pH: 7.5 T: 2°C
Assay Description:
Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
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In Depth
Details
Article
PubMed
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Target
Carbonic anhydrase 2
(Homo sapiens (Human))
Universita Degli Studi
Ligand
BDBM11331
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)
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Affinity Data
Ki: 120nM
Assay Description:
Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
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Target
Carbonic anhydrase 4
(Bos taurus (bovine))
Universita Degli Studi
Ligand
BDBM11331
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)
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Affinity Data
Ki: 145nM
Assay Description:
Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
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PC cid
PC sid
Patents
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In Depth
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Article
PubMed
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Target
Carbonic anhydrase 1
(Homo sapiens (Human))
Universita Degli Studi
Ligand
BDBM11331
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)
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Affinity Data
Ki: >200nM ΔG°: >-38.2kJ/mole
pH: 7.4 T: 2°C
Assay Description:
Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Interstitial collagenase
(Homo sapiens (Human))
Universita Degli Studi
Ligand
BDBM11331
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)
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Affinity Data
IC50: 60nM
Assay Description:
Inhibition of MMP1
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
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Target
Gelatinase
()
Artizan Biosciences
US Patent
Ligand
BDBM11331
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)
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Affinity Data
IC50: 204nM
Assay Description:
Collagenase H Assay as a Surrogate for ColA Inhibition. Different concentrations of test compound were incubated with Clostridium histolyticum collag...
More data for this Ligand-Target Pair
Target Info
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
US Patent
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Target
Bone morphogenetic protein 1
(Homo sapiens (Human))
Fibrogen
Curated by
ChEMBL
Ligand
BDBM11331
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)
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Affinity Data
IC50: 1.60E+4nM
Assay Description:
Inhibition of PCP after 1 hr by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
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Target
Meprin A subunit beta
(Homo sapiens)
Fraunhofer Institute For Cell Therapy and Immunology Izi
Curated by
ChEMBL
Ligand
BDBM11331
(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxya...)
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Affinity Data
IC50: 4.05E+4nM
Assay Description:
Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI