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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303736(5-(2-amino-1-methyl-5-oxo-4-(3-(pyridin-3-yl)pheny...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303736(5-(2-amino-1-methyl-5-oxo-4-(3-(pyridin-3-yl)pheny...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303736(5-(2-amino-1-methyl-5-oxo-4-(3-(pyridin-3-yl)pheny...)
Affinity DataIC50:  550nMAssay Description:Inhibition of human BACE2 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303736(5-(2-amino-1-methyl-5-oxo-4-(3-(pyridin-3-yl)pheny...)
Affinity DataIC50:  7.30E+3nMAssay Description:Inhibition of human cathepsin D by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50303736(5-(2-amino-1-methyl-5-oxo-4-(3-(pyridin-3-yl)pheny...)
Affinity DataEC50:  4.50E+3nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed