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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303716(2-amino-4-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-4-(4...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303716(2-amino-4-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-4-(4...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303716(2-amino-4-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-4-(4...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of human BACE2 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303716(2-amino-4-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-4-(4...)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of human cathepsin D by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303716(2-amino-4-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-4-(4...)
Affinity DataIC50:  5.76E+4nMAssay Description:Inhibition of human recombinant renin by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303716(2-amino-4-(4-fluoro-3-(pyrimidin-5-yl)phenyl)-4-(4...)
Affinity DataEC50:  40nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed