Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 15 hits in this display   

TargetCytochrome P450 1B1(Homo sapiens (Human))
Birla Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(2-(3'-Hydroxy-4'-methoxyphenyl)quinazolin-...)
Affinity DataIC50:  54nMAssay Description:Inhibition of human CYP1B1 expressed in yeast microsomal membranes using 7-ethoxyresorufin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Birla Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(2-(3'-Hydroxy-4'-methoxyphenyl)quinazolin-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant human liver CYP1B1 expressed in HEK293 cells using 7-ethoxyresorufin as substrate pretreated for 30 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Birla Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(2-(3'-Hydroxy-4'-methoxyphenyl)quinazolin-...)
Affinity DataIC50:  151nMAssay Description:Inhibition of recombinant human CYP1B1 expressed in yeast cells using 7-ethoxyresorufin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-glucuronidase(Homo sapiens (Human))
University Of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50019170(2-(3'-Hydroxy-4'-methoxyphenyl)quinazolin-...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-d-glucuronide as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-glucuronidase(Homo sapiens (Human))
University Of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50019170(2-(3'-Hydroxy-4'-methoxyphenyl)quinazolin-...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-glucuronidase(Bos taurus (Bovine))
University Of Karachi

Curated by ChEMBL
LigandPNGBDBM50019170(2-(3'-Hydroxy-4'-methoxyphenyl)quinazolin-...)
Affinity DataIC50:  2.80E+3nMAssay Description:Antagonistic activity for inhibition of histamine H2 receptor from anesthetized ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Homo sapiens (Human))
Birla Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(2-(3'-Hydroxy-4'-methoxyphenyl)quinazolin-...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of recombinant human CYP1A1 expressed in yeast cells using 7-ethoxyresorufin/3-cyano-7-ethoxycoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Homo sapiens (Human))
Birla Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(2-(3'-Hydroxy-4'-methoxyphenyl)quinazolin-...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of human CYP1A1 expressed in yeast microsomal membranes using 7-ethoxyresorufin/3-cyano-7-ethoxycoumarin as substrate by fluorescence assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A1(Homo sapiens (Human))
Birla Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(2-(3'-Hydroxy-4'-methoxyphenyl)quinazolin-...)
Affinity DataIC50: >4.50E+3nMAssay Description:Inhibition of recombinant human liver CYP1A1 expressed in HEK293 cells using 7-ethoxyresorufin as substrate pretreated for 30 mins followed by substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Birla Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(2-(3'-Hydroxy-4'-methoxyphenyl)quinazolin-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP1A2 expressed in yeast microsomal membranes using 7-ethoxyresorufin/3-cyano-7-ethoxycoumarin/7-ethoxy-methyloxy-3-cyanocoumari...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Birla Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(2-(3'-Hydroxy-4'-methoxyphenyl)quinazolin-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP3A4 expressed in yeast microsomal membranes using dibenzylfluorescein as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Birla Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(2-(3'-Hydroxy-4'-methoxyphenyl)quinazolin-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human CYP2D6 expressed in yeast microsomal membranes using 7-ethoxy-methyloxy-3-cyanocoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Birla Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(2-(3'-Hydroxy-4'-methoxyphenyl)quinazolin-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human CYP2C19 expressed in yeast microsomal membranes using 3-cyano-7-ethoxycoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Birla Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50019170(2-(3'-Hydroxy-4'-methoxyphenyl)quinazolin-...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human CYP2C9 expressed in yeast microsomal membranes using 3-cyano-7-ethoxycoumarin as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Escherichia coli (Enterobacteria))
University of Karachi

LigandPNGBDBM50019170(2-(3'-Hydroxy-4'-methoxyphenyl)quinazolin-...)
Affinity DataIC50:  1.69E+5nMpH: 7.0Assay Description:TP inhibition assay was performed spectrophotometrically. The method of Bera et al. was followed with slight modifications. Reaction mixture of 200 µ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed