Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Cephalon

LigandPNGBDBM24947(3-(2-hydroxyethyl)-20-methoxy-3,13-diazahexacyclo[...)
Affinity DataIC50:  55nMpH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Cephalon

LigandPNGBDBM24947(3-(2-hydroxyethyl)-20-methoxy-3,13-diazahexacyclo[...)
Affinity DataIC50:  103nMpH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Cephalon

LigandPNGBDBM24947(3-(2-hydroxyethyl)-20-methoxy-3,13-diazahexacyclo[...)
Affinity DataIC50:  1.27E+3nMAssay Description:Compounds were evaluated for their ability to inhibit the kinase activity of TrkA using an ELISA-based assay. The 96-well microtiter plate is coated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 10(Homo sapiens (Human))
Cephalon

LigandPNGBDBM24947(3-(2-hydroxyethyl)-20-methoxy-3,13-diazahexacyclo[...)
Affinity DataIC50:  1.58E+3nMpH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon

LigandPNGBDBM24947(3-(2-hydroxyethyl)-20-methoxy-3,13-diazahexacyclo[...)
Affinity DataIC50:  4.72E+3nMAssay Description:Compounds were evaluated for their ability to inhibit the kinase activity using an ELISA-based assay. The 96-well microtiter plate is coated with sub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed