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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetGenome polyprotein(Hepatitis C virus)
TBA

Curated by ChEMBL
LigandPNGBDBM50336504((2R,3aR,10Z,11aS,12aR,14aR)-N-(cyclopropylsulfonyl...)
Affinity DataKi:  0.360nMAssay Description:Inhibition of HCV genotype 1a NS3/4A protease using Ac-DED(Edans)EEAbu-psi[COO]ASK(Dabcyl)-NH2 as substrate by FRET assayMore data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus)
Janssen Ireland

US Patent
LigandPNGBDBM50336504((2R,3aR,10Z,11aS,12aR,14aR)-N-(cyclopropylsulfonyl...)
Affinity DataKi:  0.5nM ΔG°:  -54.0kJ/molepH: 7.5 T: 2°CAssay Description:The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus)
Janssen Ireland

US Patent
LigandPNGBDBM50336504((2R,3aR,10Z,11aS,12aR,14aR)-N-(cyclopropylsulfonyl...)
Affinity DataKi:  0.5nMAssay Description:The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay p...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Tibotec

Curated by ChEMBL
LigandPNGBDBM50336504((2R,3aR,10Z,11aS,12aR,14aR)-N-(cyclopropylsulfonyl...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human cathepsin S in human JY cells assessed as p10 accumulation by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed