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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 19 hits in this display   

TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [125I-HEAT from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [125I-HEAT from human alpha1A-adrenoreceptor expressed in CHOK1 cell membranes incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Affinity DataKi:  3.70nMAssay Description:Binding constant measured against Alpha-1A adrenergic receptor in human prostate; ++:moderately activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Affinity DataKi:  5.90nMAssay Description:Binding affinity to adrenergic alpha1A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Affinity DataKi:  5.90nMAssay Description:Binding affinity to adrenergic alpha1A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Affinity DataKi:  20nMAssay Description:Displacement of [125I-HEAT from human alpha1B-adrenoreceptor expressed in CHOK1 cell membranes incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Università

Curated by ChEMBL
LigandPNGBDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Affinity DataKi:  39nMAssay Description:Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Rattus norvegicus (Rat))
Università

Curated by ChEMBL
LigandPNGBDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Affinity DataKi: >1.00E+3nMAssay Description:Compound was evaluated for its Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat hea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Canis familiaris)
Università

Curated by ChEMBL
LigandPNGBDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Affinity DataKi:  1.00E+3nMAssay Description:Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Affinity DataKi:  1.60E+3nMAssay Description:Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Affinity DataIC50:  55nMAssay Description:Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Affinity DataIC50:  55nMAssay Description:Antagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Affinity DataIC50:  555nMAssay Description:Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Affinity DataIC50:  555nMAssay Description:Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Affinity DataIC50:  634nMAssay Description:Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Guangzhou Medical University

Curated by ChEMBL
LigandPNGBDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Affinity DataIC50:  634nMAssay Description:Antagonist activity at alpha 1B adrenergic receptor (unknown origin) by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycoprotein 42(Human herpesvirus 4 type 2)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Affinity DataIC50:  1.41E+4nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Theodore Jardetzky; Northw...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM50773(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Affinity DataEC50:  3.72E+3nMAssay Description:Assay Provider: Xinmin Xie Assay Provider Affiliation: Bioscience Division, SRI International, Menlo Park, CA Grant Title: HTS Assay for Cav3 T-Type ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay