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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
19
hits in this display
Target
Alpha-1D adrenergic receptor
(Homo sapiens (Human))
Guangzhou Medical University
Curated by
ChEMBL
Ligand
BDBM50773
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
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Affinity Data
Ki: 1.20nM
Assay Description:
Displacement of [125I-HEAT from human alpha1D-adrenoreceptor expressed in CHOK1 cell membranes incubated for 60 mins
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Guangzhou Medical University
Curated by
ChEMBL
Ligand
BDBM50773
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
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Affinity Data
Ki: 3.70nM
Assay Description:
Displacement of [125I-HEAT from human alpha1A-adrenoreceptor expressed in CHOK1 cell membranes incubated for 60 mins
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Guangzhou Medical University
Curated by
ChEMBL
Ligand
BDBM50773
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
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Affinity Data
Ki: 3.70nM
Assay Description:
Binding constant measured against Alpha-1A adrenergic receptor in human prostate; ++:moderately active
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Guangzhou Medical University
Curated by
ChEMBL
Ligand
BDBM50773
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
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Affinity Data
Ki: 5.90nM
Assay Description:
Binding affinity to adrenergic alpha1A receptor (unknown origin)
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Guangzhou Medical University
Curated by
ChEMBL
Ligand
BDBM50773
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 5.90nM
Assay Description:
Binding affinity to adrenergic alpha1A receptor (unknown origin)
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Target
Alpha-1B adrenergic receptor
(Homo sapiens (Human))
Guangzhou Medical University
Curated by
ChEMBL
Ligand
BDBM50773
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 20nM
Assay Description:
Displacement of [125I-HEAT from human alpha1B-adrenoreceptor expressed in CHOK1 cell membranes incubated for 60 mins
More data for this Ligand-Target Pair
Target Info
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat))
Università
Curated by
ChEMBL
Ligand
BDBM50773
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
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Affinity Data
Ki: 39nM
Assay Description:
Alpha-1 adrenergic receptor binding affinity by measuring the displacement of [3H]prazosin binding in rat brain
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Target
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat))
Università
Curated by
ChEMBL
Ligand
BDBM50773
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Compound was evaluated for its Beta-1 adrenergic receptor binding affinity by measuring the displacement of [3H]-dihydroalprenolol binding in rat hea...
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Target
Beta-2 adrenergic receptor
(Canis familiaris)
Università
Curated by
ChEMBL
Ligand
BDBM50773
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
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Affinity Data
Ki: 1.00E+3nM
Assay Description:
Beta-2 adrenergic receptor binding affinity by measuring the displacement of [3H]-DHA binding in rat lung
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Target
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT)
Università
Curated by
ChEMBL
Ligand
BDBM50773
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
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Affinity Data
Ki: 1.60E+3nM
Assay Description:
Alpha-2 adrenergic receptor binding affinity by measuring the displacement of [3H]clonidine binding in rat cerebral cortex
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Target
Alpha-1D adrenergic receptor
(Homo sapiens (Human))
Guangzhou Medical University
Curated by
ChEMBL
Ligand
BDBM50773
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
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Affinity Data
IC50: 55nM
Assay Description:
Antagonist activity at adrenergic alpha1D receptor (unknown origin) by firefly and renilla dual glo luciferase assay
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Target
Alpha-1D adrenergic receptor
(Homo sapiens (Human))
Guangzhou Medical University
Curated by
ChEMBL
Ligand
BDBM50773
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 55nM
Assay Description:
Antagonist activity at alpha 1D adrenergic receptor (unknown origin) by luciferase reporter gene assay
More data for this Ligand-Target Pair
Target Info
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Guangzhou Medical University
Curated by
ChEMBL
Ligand
BDBM50773
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 555nM
Assay Description:
Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
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CHEMBL
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Article
PubMed
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Target
Alpha-1A adrenergic receptor
(Homo sapiens (Human))
Guangzhou Medical University
Curated by
ChEMBL
Ligand
BDBM50773
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 555nM
Assay Description:
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Alpha-1B adrenergic receptor
(Homo sapiens (Human))
Guangzhou Medical University
Curated by
ChEMBL
Ligand
BDBM50773
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 634nM
Assay Description:
Antagonist activity at adrenergic alpha1B receptor (unknown origin) by firefly and renilla dual glo luciferase assay
More data for this Ligand-Target Pair
Target Info
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Target
Alpha-1B adrenergic receptor
(Homo sapiens (Human))
Guangzhou Medical University
Curated by
ChEMBL
Ligand
BDBM50773
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 634nM
Assay Description:
Antagonist activity at alpha 1B adrenergic receptor (unknown origin) by luciferase reporter gene assay
More data for this Ligand-Target Pair
Target Info
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UniProtKB/SwissProt
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Target
Bile salt export pump
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50773
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
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Affinity Data
IC50: <1.00E+4nM
Assay Description:
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...
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Target
Glycoprotein 42
(Human herpesvirus 4 type 2)
Emory University
Curated by
PubChem BioAssay
Ligand
BDBM50773
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
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Affinity Data
IC50: 1.41E+4nM
Assay Description:
NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Theodore Jardetzky; Northw...
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Target
Voltage-dependent T-type calcium channel subunit alpha-1H
(Homo sapiens (Human))
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters
Curated by
PubChem BioAssay
Ligand
BDBM50773
(1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphtha...)
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Affinity Data
EC50: 3.72E+3nM
Assay Description:
Assay Provider: Xinmin Xie Assay Provider Affiliation: Bioscience Division, SRI International, Menlo Park, CA Grant Title: HTS Assay for Cav3 T-Type ...
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