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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
39
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Target
5-hydroxytryptamine receptor 6
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: 1.20nM
Assay Description:
Binding affinity against 5 Hydroxy tryptamine 6 receptor
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: 9.5nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 1A receptor by displacing [3H]WB-4101 from rat hippocampus
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 9.5nM
Assay Description:
Binding affinity at rat 5-hydroxytryptamine 1A receptor by [3H]-WB-4101 displacement.
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
Copy SMILES
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Affinity Data
Ki: 12.9nM
Assay Description:
Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
Copy SMILES
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Affinity Data
Ki: 13nM
Assay Description:
Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement
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Target
5-hydroxytryptamine receptor 1B
(Rattus norvegicus (Rat))
Mcneil Pharmaceutical And Janssen Research Foundation Worldwide
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: 17nM
Assay Description:
Binding affinity at rat 5-hydroxytryptamine 1B receptor by [3H]-5-HT displacement.
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Target
5-hydroxytryptamine receptor 1A/1B/1D/1F
(RAT)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: 28nM
Assay Description:
The compound was tested for its binding affinity towards 5-hydroxytryptamine 1 receptor by displacing [3H]5-HT radioligand in rat cerebral cortex
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Target
5-hydroxytryptamine receptor 1A/1B/1D/1F
(RAT)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: 29nM
Assay Description:
Inhibition of [3H]5-HT radioligand binding against 5-hydroxytryptamine 1 receptor
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
Copy SMILES
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Affinity Data
Ki: 68nM
Assay Description:
Binding affinity towards rat 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT radioligand.
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
Copy SMILES
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Affinity Data
Ki: 68nM
Assay Description:
Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: >100nM
Assay Description:
The compound was tested for its binding affinity towards 5-hydroxytryptamine 2 receptor by displacing [3H]ketanserin radioligand in rat cerebral cort...
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Target
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
National Institute of Neurological Disorders and Stroke
Curated by
PDSP K
i
Database
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: 125nM
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Target
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
National Institute of Neurological Disorders and Stroke
Curated by
PDSP K
i
Database
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
Copy SMILES
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Affinity Data
Ki: 126nM
Assay Description:
Binding affinity at rat 5-hydroxytryptamine 7 receptor.
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
Copy SMILES
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Affinity Data
Ki: 170nM
Assay Description:
Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: 170nM
Assay Description:
Displacement of radioligand [3H]-2-(di-N-propylamino)-8-hydroxytetralin from 5-hydroxytryptamine 1A receptor in rat frontal cortex homogenate
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 170nM
Assay Description:
Displacement of [3H]-2-(di-N-propylamino)-8-hydroxytetralin from central 5-hydroxytryptamine 1A receptor recognition sites in rat frontal cortex homo...
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Target
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
National Institute of Neurological Disorders and Stroke
Curated by
PDSP K
i
Database
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
Copy SMILES
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Affinity Data
Ki: 243nM
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Target
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat))
National Institute of Neurological Disorders and Stroke
Curated by
PDSP K
i
Database
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 243nM
Assay Description:
Displacement of [3H]LSD from rat rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cells
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 281nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 1A receptor measured by displacing [3H]-8-OH-DPAT from rat cortical membranes
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Target
5-hydroxytryptamine receptor 3A
(RAT)
Virginia Commonwealth University
Curated by
PDSP K
i
Database
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: 324nM
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: 510nM
Assay Description:
The compound was tested for its binding affinity towards Alpha-1 adrenergic receptor by displacing [3H]WB-4101 radioligand in rat cerebral cortex
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Target
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: 510nM
Assay Description:
Binding affinity against rat Alpha-1 adrenergic receptor.
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: 680nM
Assay Description:
Displacement of [125I]IABN from human D2L receptor expressed in HEK293 cells after 60 mins by gamma counting analysis
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
Mcneil Pharmaceutical And Janssen Research Foundation Worldwide
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Binding affinity against rat Dopamine receptor D2.
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Target
D(1A) dopamine receptor
(RAT)
Mcneil Pharmaceutical And Janssen Research Foundation Worldwide
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Binding affinity at rat Dopamine receptor D1 by [3H]-SCH-23,390 displacement.
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Binding affinity at rat 5-hydroxytryptamine 2 receptor by [3H]ketanserin displacement.
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
Mcneil Pharmaceutical And Janssen Research Foundation Worldwide
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
Copy SMILES
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatum
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
Mcneil Pharmaceutical And Janssen Research Foundation Worldwide
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: 1.20E+3nM
Assay Description:
In vitro displacement of [3H]-spiperone from Dopamine receptor D2 binding site in rat striatum.
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: 2.26E+3nM
Assay Description:
Displacement of [125I]IABN from human D3 receptor expressed in HEK293 cells after 60 mins by gamma counting analysis
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Target
5-hydroxytryptamine receptor 3A/3B/3C/3D/3E
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: 2.50E+3nM
Assay Description:
Compound was tested for the inhibition of [3H]-GR-65,630 binding to 5-hydroxytryptamine 3 receptor expressed in NG 108-15 cells
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Target
5-hydroxytryptamine receptor 6
(RAT)
National Institute of Neurological Disorders and Stroke
Curated by
PDSP K
i
Database
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: 3.06E+3nM
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Target
Serotonin 2 (5-HT2) receptor
(RAT)
R. W. Johnson Pharmaceutical Research Institute
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: 3.50E+3nM
Assay Description:
Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor of rat cortex
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Target
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat))
Universitá
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: 3.51E+3nM
Assay Description:
Binding affinity measured for alpha-1 adrenergic receptor by displacement of [3H]-prazosin from rat cortical membranes
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: 4.11E+3nM
Assay Description:
Displacement of [3H]spiperone from human D2L receptor expressed in FlpIn CHO cell membrane after 3 hrs by liquid scintillation counting analysis
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Sigma non-opioid intracellular receptor 1
(Homo sapiens (Human))
Virginia Commonwealth University
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
Ki: 1.12E+4nM
Assay Description:
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand
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D(2) dopamine receptor
(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
IC50: >1.00E+3nM
Assay Description:
Antagonist activity at human D2L receptor expressed in FlpIn CHO cells assessed as inhibition of dopamine-induced ERK1/2 phosphorylation treated for ...
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Beta-1 adrenergic receptor
(Homo sapiens (Human))
Berlex Laboratories
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
IC50: 2.00E+3nM
Assay Description:
Binding affinity for Beta-1 adrenergic receptor by displacing [3H]dihydroalprenolol, in partially purified membrane fractions from canine ventricular...
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Replicase polyprotein 1ab
(2019-nCoV)
Cornell University
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
IC50: 2.98E+3nM
Assay Description:
IC50 values were determined for the whole plate in case of Chan-Lam coupling, using 5 point 3-fold dilutions (starting from 10 μM).
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Beta-2 adrenergic receptor
(Canis familiaris)
Berlex Laboratories
Curated by
ChEMBL
Ligand
BDBM50001862
((N-(o-methoxyphenyl)piperazine)1-(2-Methoxy-phenyl...)
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Affinity Data
IC50: 3.40E+4nM
Assay Description:
Binding affinity towards Beta-2 adrenergic receptor by displacing [3H]dihydroalprenolol, in partially purified membrane fractions from canine lung ti...
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