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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
14
hits in this display
Target
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50359088
(CHEMBL1229205)
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Affinity Data
IC50: 0.600nM
Assay Description:
Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
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Article
PubMed
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Target
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50359088
(CHEMBL1229205)
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Copy InChI
Affinity Data
IC50: 2nM
Assay Description:
Displacement of [3H]-3-[5-(pyrid-2-ylmethoxy)-3-tert-butylthio-1-benzylindol-2-yl]-2,2-dimethylpropionic acid from FLAP in human polymorphonuclear ce...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50322851
(CHEMBL1210423 | sodium 3-(3-(tert-butylthio)-1-(4-...)
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Affinity Data
IC50: 2nM
Assay Description:
Binding affinity to FLAP in human PMN by radioligand displacement assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50359088
(CHEMBL1229205)
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Affinity Data
IC50: 4.5nM
Assay Description:
Inhibition of human CYP2C9
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50359088
(CHEMBL1229205)
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Affinity Data
IC50: 8.80nM
Assay Description:
Inhibition of human CYP3A4
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50359088
(CHEMBL1229205)
Copy SMILES
Copy InChI
Affinity Data
IC50: >50nM
Assay Description:
Inhibition of human CYP2D6
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50359088
(CHEMBL1229205)
Copy SMILES
Copy InChI
Affinity Data
IC50: 81nM
Assay Description:
Inhibition of FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 5 hrs by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50359088
(CHEMBL1229205)
Copy SMILES
Copy InChI
Affinity Data
IC50: 161nM
Assay Description:
Inhibition of FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 15 mins by ELISA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50322851
(CHEMBL1210423 | sodium 3-(3-(tert-butylthio)-1-(4-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.50E+3nM
Assay Description:
Inhibition of CYP2C9
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50322851
(CHEMBL1210423 | sodium 3-(3-(tert-butylthio)-1-(4-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 8.80E+3nM
Assay Description:
Inhibition of CYP3A4
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prostaglandin G/H synthase 1
(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50359088
(CHEMBL1229205)
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Affinity Data
IC50: 2.50E+4nM
Assay Description:
Inhibition of COX1-mediated TXB2 production in human whole blood after 30 mins by competitive enzyme immunoassay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50322851
(CHEMBL1210423 | sodium 3-(3-(tert-butylthio)-1-(4-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >3.00E+4nM
Assay Description:
Inhibition of CYP2D6
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prostaglandin G/H synthase 1
(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50322851
(CHEMBL1210423 | sodium 3-(3-(tert-butylthio)-1-(4-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of COX1
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
Amira Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50322851
(CHEMBL1210423 | sodium 3-(3-(tert-butylthio)-1-(4-...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >1.00E+5nM
Assay Description:
Inhibition of COX2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI