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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
Beta-secretase 2
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM335460
((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- ...)
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Affinity Data
Ki: 21nM
Assay Description:
The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
Beta-secretase 1
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM335460
((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- ...)
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Affinity Data
Ki: 67nM
Assay Description:
The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Cathepsin D
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM335460
((3R,6S)-5-amino-6- cyclopropyl-3-(5-fluoro-2-((7- ...)
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Affinity Data
Ki: 9.30E+3nM
Assay Description:
The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI