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Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
14
hits in this display
Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM15458
(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
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Affinity Data
Ki: 36nM
Assay Description:
Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Tyrosine-protein kinase Lck
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM15458
(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
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Affinity Data
IC50: >10nM
Assay Description:
Inhibition of p56 Lck kinase
More data for this Ligand-Target Pair
Target Info
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Target
Epidermal growth factor receptor
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM15458
(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
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Affinity Data
IC50: >10nM
Assay Description:
Inhibition of EGFR kinase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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Target
Protein kinase C beta type
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM15458
(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
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Affinity Data
IC50: 17nM
Assay Description:
Inhibition of PKC-beta2 kinase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM15458
(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
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Affinity Data
IC50: 19nM
Assay Description:
Inhibition against Mitogen-activated protein kinase p38 alpha
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
UniProtKB/SwissProt
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CHEMBL
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PubMed
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Target
Mitogen-activated protein kinase 9
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM15458
(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
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Affinity Data
IC50: >20nM
Assay Description:
Inhibition of JNK 2 beta2 kinase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM15458
(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
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Affinity Data
IC50: 40nM
Assay Description:
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...
More data for this Ligand-Target Pair
Target Info
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Target
Dual specificity mitogen-activated protein kinase kinase 2
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM15458
(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
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Affinity Data
IC50: >50nM
Assay Description:
Inhibition of ERK2 kinase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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antibodypedia
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CHEMBL
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Target
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM15458
(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
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Affinity Data
IC50: >50nM
Assay Description:
Inhibition of cRaf kinase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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CHEMBL
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Target
Mitogen-activated protein kinase 8
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM15458
(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
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Affinity Data
IC50: >50nM
Assay Description:
Inhibition of JNK1 kinase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
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CHEMBL
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Target
Protein kinase C alpha type
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM15458
(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
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Affinity Data
IC50: 83nM
Assay Description:
Inhibition of PKCalpha kinase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
UniProtKB/SwissProt
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DrugBank
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CHEMBL
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Target
Cyclin-dependent kinase 1
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM15458
(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
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Affinity Data
IC50: >100nM
Assay Description:
Inhibition of cdc2 kinase
More data for this Ligand-Target Pair
Target Info
PDB
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CHEMBL
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PubMed
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Target
Mitogen-activated protein kinase 14
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM15458
(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
Copy SMILES
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Affinity Data
IC50: 130nM
Assay Description:
Inhibition of p38alpha phosphorylation in IL1alpha-stimulated HLF cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
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Target
Heat shock protein beta-1
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM15458
(4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
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Affinity Data
IC50: 160nM
Assay Description:
Inhibition of HSP27 phosphorylation in IL1alpha-stimulated HLF cells
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
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KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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PC sid
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In Depth
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PubMed
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