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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetBromodomain-containing protein 3(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM264438(5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl...)
Affinity DataIC50:  24nMpH: 7.5Assay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM264438(5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl...)
Affinity DataIC50:  32nMpH: 7.5Assay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM264438(5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl...)
Affinity DataIC50:  41nMpH: 7.5Assay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM264437(5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl...)
Affinity DataIC50:  65nMpH: 7.5Assay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM264437(5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl...)
Affinity DataIC50:  76nMpH: 7.5Assay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM264437(5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl...)
Affinity DataIC50:  110nMpH: 7.5Assay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCREB-binding protein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM264438(5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl...)
Affinity DataIC50:  1.90E+3nMpH: 7.5 T: 2°CAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCREB-binding protein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM264437(5-(5-chloro-1-methyl-6-oxo-1,6-dihydropyridin-3-yl...)
Affinity DataIC50:  4.40E+3nMpH: 7.5 T: 2°CAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent