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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
27
hits in this display
Target
Bromodomain-containing protein 4
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
Ki: 5nM
Assay Description:
Displacement of Alexa647-labeled JQ1 derivative from wild type BRD4 tandem domain (44 to 460 residues) (unknown origin) incubated for 1 hr by fluores...
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Target
Bromodomain-containing protein 4
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
Ki: 5nM
Assay Description:
Inhibition of BRD4 (unknown origin)
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Target
Bromodomain-containing protein 4
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
Ki: 50nM
Assay Description:
Inhibition of human BRD4 bromodomain 1 expressed in bacterial expression system
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Target
Bromodomain-containing protein 3
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
Ki: 63nM
Assay Description:
Inhibition of human BRD3 bromodomain 1 expressed in bacterial expression system
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Target
Bromodomain-containing protein 2
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
Ki: 100nM
Assay Description:
Inhibition of human BRD2 bromodomain 1 expressed in bacterial expression system
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Target
Bromodomain testis-specific protein
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
Ki: 100nM
Assay Description:
Inhibition of human BRDT bromodomain 1 expressed in bacterial expression system
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Target
Bromodomain-containing protein 4
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
Ki: 126nM
Assay Description:
Displacement of Alexa647-labeled JQ1 derivative from wild type BRD4 bromodomain 2 (44 to 460 residues) N433A mutant (unknown origin) incubated for 1 ...
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Target
Bromodomain-containing protein 4
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
Ki: 126nM
Assay Description:
Inhibition of human BRD4 bromodomain 2 expressed in bacterial expression system
More data for this Ligand-Target Pair
Target Info
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Target
Bromodomain-containing protein 4
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
Ki: 158nM
Assay Description:
Displacement of Alexa647-labeled JQ1 derivative from wild type BRD4 bromodomain 1 (44 to 460 residues) N140A mutant (unknown origin) incubated for 1 ...
More data for this Ligand-Target Pair
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Target
Bromodomain-containing protein 2
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
Ki: 251nM
Assay Description:
Inhibition of human BRD2 bromodomain 2 expressed in bacterial expression system
More data for this Ligand-Target Pair
Target Info
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Target
Bromodomain-containing protein 3
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
Ki: 398nM
Assay Description:
Inhibition of human BRD3 bromodomain 2 expressed in bacterial expression system
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Target Info
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Target
Bromodomain testis-specific protein
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
Ki: 501nM
Assay Description:
Inhibition of human BRDT bromodomain 2 expressed in bacterial expression system
More data for this Ligand-Target Pair
Target Info
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Target
Transcription initiation factor TFIID subunit 1
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
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Affinity Data
Ki: 1.26E+3nM
Assay Description:
Inhibition of human TAF1 bromodomain 2 expressed in bacterial expression system
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Target
Bromodomain-containing protein 9
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
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Affinity Data
Ki: 2.51E+3nM
Assay Description:
Inhibition of human BRD9 expressed in bacterial expression system
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Target
Transcription initiation factor TFIID subunit 1-like
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
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Affinity Data
Ki: 2.51E+3nM
Assay Description:
Inhibition of human TAF1L bromodomain 2 expressed in bacterial expression system
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Target
CREB-binding protein
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
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Affinity Data
Ki: 6.31E+3nM
Assay Description:
Inhibition of human CREBBP expressed in bacterial expression system
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Target
Histone acetyltransferase p300
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Inhibition of human EP300 expressed in bacterial expression system
More data for this Ligand-Target Pair
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Target
Bromodomain-containing protein 4
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.60nM
Assay Description:
Inhibition of BRD4 (unknown origin) BD1 domain incubated for 18 hrs
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Target
Bromodomain-containing protein 4
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5nM
Assay Description:
Inhibition of recombinant human N-terminal His6-tagged BRD4 bromodomain 1 expressed in Escherichia coli BL21(DE3) using biotinylated histone peptide ...
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Target
Bromodomain-containing protein 4
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5nM
Assay Description:
Inhibition of full length BRD4 (unknown origin) incubated for 18 hrs
More data for this Ligand-Target Pair
Target Info
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Target
Bromodomain-containing protein 4
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5nM
Assay Description:
Inhibition of BRD4 BD2 (unknown origin) by chromatin/BRD4 displacement assay
More data for this Ligand-Target Pair
Target Info
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Target
Bromodomain-containing protein 4
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5nM
Assay Description:
Inhibition of BRD4 BD1 (unknown origin) by chromatin/BRD4 displacement assay
More data for this Ligand-Target Pair
Target Info
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Target
Bromodomain-containing protein 4
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5nM
Assay Description:
Inhibition of BRD4 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Bromodomain-containing protein 4
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
IC50: 13nM
Assay Description:
Inhibition of BRD4 in human MM1S cells assessed as down regulation of c-Myc incubated for 16 hrs by flow cytometry
More data for this Ligand-Target Pair
Target Info
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Target
Bromodomain-containing protein 4
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
IC50: 20nM
Assay Description:
Inhibition of BRD4 in human LNCAP cells assessed as down regulation of nuclear AR level by immunofluorescence assay
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Bromodomain-containing protein 4
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
IC50: 25nM
Assay Description:
Inhibition of BRD4 in human MCF7 cells assessed as down regulation of ERalpha after 18 to 24 hrs by Hoechst staining based cellomics arrayscan analys...
More data for this Ligand-Target Pair
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Target
Bromodomain-containing protein 4
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50260093
(CHEMBL4078100)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.60E+3nM
Assay Description:
Displacement of Halo-tagged histone H3.3 from N-terminal NanoLuc-tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) expressed in HCT116 ...
More data for this Ligand-Target Pair
Target Info
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PC cid
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PDB
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