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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 9 hits in this display   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50361170(CHEMBL4159366)
Affinity DataIC50:  2nMAssay Description:Inhibition of JAK2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor corepressor 1(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50361170(CHEMBL4159366)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant HDAC3/GST-tagged NCOR1 (397 to 503 residues) co-expressed in insect cells using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50361170(CHEMBL4159366)
Affinity DataIC50:  18nMAssay Description:Inhibition of full length human recombinant HDAC1 expressed in baculovirus expression system using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50361170(CHEMBL4159366)
Affinity DataIC50:  74nMAssay Description:Inhibition of full length human recombinant HDAC6 expressed in Baculovirus infected Sf9 cells using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50361170(CHEMBL4159366)
Affinity DataIC50:  74nMAssay Description:Inhibition of TYK2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50361170(CHEMBL4159366)
Affinity DataIC50:  76nMAssay Description:Inhibition of JAK1 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50361170(CHEMBL4159366)
Affinity DataIC50:  132nMAssay Description:Inhibition of recombinant HDAC2 (unknown origin) using (Ac-Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50361170(CHEMBL4159366)
Affinity DataIC50:  144nMAssay Description:Inhibition of JAK3 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition and measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50361170(CHEMBL4159366)
Affinity DataIC50:  572nMAssay Description:Inhibition of full length recombinant C-terminal His tagged human HDAC8 expressed in Baculovirus infected Sf9 cells using Ac-Leu-Gly-Lys(Tfa)-AMC as ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed