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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetS-methyl-5'-thioinosine phosphorylase(Pseudomonas aeruginosa)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM50246594((+/-)-7-((1-hydroxy-3-(methylthio)propan-2-ylamino...)
Affinity DataKi:  0.0960nM ΔG°:  -57.2kJ/molepH: 7.4 T: 2°CAssay Description:Assays for slow-onset inhibitors were carried out by adding 1 nM PaMTIP into reaction mixtures at 25 °C. containing 100 mM Hepes, pH 7.4, 100 mM ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetS-methyl-5'-thioinosine phosphorylase(Pseudomonas aeruginosa)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM50246594((+/-)-7-((1-hydroxy-3-(methylthio)propan-2-ylamino...)
Affinity DataKi:  0.0960nM ΔG°:  -57.2kJ/molepH: 7.4 T: 2°CAssay Description:Assays for slow-onset inhibitors were carried out by adding 1 nM PaMTIP into reaction mixtures at 25 °C. containing 100 mM Hepes, pH 7.4, 100 mM ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetS-methyl-5'-thioinosine phosphorylase(Pseudomonas aeruginosa)
Albert Einstein College of Medicine

US Patent
LigandPNGBDBM50246594((+/-)-7-((1-hydroxy-3-(methylthio)propan-2-ylamino...)
Affinity DataKi:  0.720nM ΔG°:  -52.2kJ/molepH: 7.4 T: 2°CAssay Description:Assays for slow-onset inhibitors were carried out by adding 1 nM PaMTIP into reaction mixtures at 25 °C. containing 100 mM Hepes, pH 7.4, 100 mM ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Albert Einstein College Of Medicine Of Yeshiva University

Curated by ChEMBL
LigandPNGBDBM50246594((+/-)-7-((1-hydroxy-3-(methylthio)propan-2-ylamino...)
Affinity DataKi:  4.30nMAssay Description:Initial binding affinity to wild type human PNPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed