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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
207
hits in this display
Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
Ki: 0.540nM
Assay Description:
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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Target
Histone deacetylase 4
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
Ki: 0.600nM
Assay Description:
Competitive inhibition of HDAC4 using KI-104 as substrate by fluorescence assay
More data for this Ligand-Target Pair
Target Info
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MMDB
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KEGG
UniProtKB/SwissProt
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Target
Histone deacetylase 5
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.700nM
Assay Description:
Competitive inhibition of HDAC5 using KI-104 as substrate by fluorescence assay
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
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Target
Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.700nM
Assay Description:
Competitive inhibition of HDAC6 using KI-104 as substrate by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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Target
Histone deacetylase 2
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
Ki: 0.700nM
Assay Description:
Inhibition of human HDAC2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1nM
Assay Description:
Inhibition of human HDAC1
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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Target
Histone deacetylase 3
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
Ki: 1.10nM
Assay Description:
Inhibition of human HDAC3
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 9
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
Ki: 1.20nM
Assay Description:
Competitive inhibition of HDAC9 using KI-104 as substrate by fluorescence assay
More data for this Ligand-Target Pair
Target Info
Reactome pathway
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Target
Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.5nM
Assay Description:
Inhibition of human HDAC6
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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Target
Histone deacetylase 2
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
Ki: 1.90nM
Assay Description:
Competitive inhibition of HDAC2 using KI-104 as substrate by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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Target
Histone deacetylase 7
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
Ki: 2.30nM
Assay Description:
Competitive inhibition of HDAC7 using KI-104 as substrate by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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Target
Histone deacetylase 3
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.30nM
Assay Description:
Competitive inhibition of HDAC3 using KI-104 as substrate by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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MCE
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Article
PubMed
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Target
Histone deacetylase 3
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.40nM
Assay Description:
Inhibition of human recombinant HDAC3 using fluorogenic HDAC substrate after 10 mins by spectrophotometric method
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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MCE
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.5nM
Assay Description:
Competitive inhibition of HDAC1 using KI-104 as substrate by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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MCE
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3nM
Assay Description:
Inhibition of human recombinant HDAC1 using fluorogenic HDAC substrate after 15 mins by fluorimetrc method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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MCE
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In Depth
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Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 11
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.5nM
Assay Description:
Competitive inhibition of HDAC11 using KI-104 as substrate by fluorescence assay
More data for this Ligand-Target Pair
Target Info
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
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MCE
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Target
Polyamine deacetylase HDAC10
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 5.10nM
Assay Description:
Inhibition of human recombinant HDAC10 using fluorogenic HDAC substrate after 45 mins by fluorimetrc method
More data for this Ligand-Target Pair
Target Info
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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MCE
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Target
Histone deacetylase 2
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 13nM
Assay Description:
Inhibition of C-terminal GST-tagged recombinant human HDAC2 (1 to 488 residues) expressed in Baculovirus infected insect cells using Boc-Lys(Ac)-AMC ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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MCE
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Target
Histone deacetylase 8
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 22nM
Assay Description:
Competitive inhibition of HDAC8 using KI-104 as substrate by fluorescence assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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MCE
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 2
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 22nM
Assay Description:
Inhibition of human recombinant HDAC2 using fluorogenic HDAC substrate after 15 mins by fluorimetrc method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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MCE
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Target
Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 30nM
Assay Description:
Inhibition of N-terminal GST-tagged recombinant human HDAC6 (1 to 1215 residues) expressed in Baculovirus infected insect cells using Boc-Lys(Ac)-AMC...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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MCE
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Target
Polyamine deacetylase HDAC10
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 31nM
Assay Description:
Competitive inhibition of HDAC10 using KI-104 as substrate by fluorescence assay
More data for this Ligand-Target Pair
Target Info
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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MCE
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Target
Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 54nM
Assay Description:
Inhibition of human recombinant HDAC6 using fluorogenic HDAC substrate after 30 mins by fluorimetrc method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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MCE
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Target
Histone deacetylase 5
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 57nM
Assay Description:
Inhibition of human recombinant HDAC5 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc method
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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MCE
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In Depth
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Copy BDB DOI
Target
Histone deacetylase 5
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 80nM
Assay Description:
Inhibition of human HDAC5
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
MCE
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PC sid
PDB
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 8
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 105nM
Assay Description:
Inhibition of human HDAC8
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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MCE
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Article
PubMed
Copy BDB DOI
Target
Histone deacetylase 8
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 170nM
Assay Description:
Inhibition of human recombinant HDAC8 using fluorogenic HDAC substrate after 15 mins by fluorimetrc method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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MCE
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Target
Histone deacetylase 4
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 170nM
Assay Description:
Inhibition of human recombinant HDAC4 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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MCE
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Target
Histone deacetylase 4
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 550nM
Assay Description:
Inhibition of human HDAC4
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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MCE
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Target
Histone deacetylase 7
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 630nM
Assay Description:
Inhibition of human recombinant HDAC7 using fluorogenic HDAC substrate class 2a after 45 mins by fluorimetrc method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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MCE
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Target
Histone deacetylase 4
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 640nM
Assay Description:
Inhibition of C-terminal His-tagged/N-terminal GST-tagged recombinant human HDAC4 (627 to 1084 residues) expressed in Baculovirus infected insect cel...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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MCE
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Target
Histone deacetylase 8
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
Ki: 750nM
Assay Description:
Inhibition of C-terminal His-fusion tagged/N-terminal Strep-2 tagged recombinant human HDAC8 (1 to 377 residues) expressed in insect cells using Boc-...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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MCE
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Target
Histone deacetylase 9
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
Ki: 830nM
Assay Description:
Inhibition of human recombinant HDAC9 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc method
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 11
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
Ki: 1.20E+3nM
Assay Description:
Inhibition of human recombinant HDAC11 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc method
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Histone deacetylase 9
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
Ki: 3.20E+3nM
Assay Description:
Inhibition of human HDAC9
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Histone deacetylase 7
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
Ki: 4.55E+3nM
Assay Description:
Inhibition of human HDAC7
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Target
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Inhibition of human recombinant SIRT1 using fluorogenic HDAC substrate after 20 mins by fluorimetrc method
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Target
NAD-dependent protein deacetylase sirtuin-7
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Inhibition of SIRT7 (unknown origin)
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Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Inhibition of human recombinant SIRT3 using fluoro-lysine sirtuin 2 deacetylase substrate after 45 mins by fluorimetrc method
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Target
NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Inhibition of human recombinant SIRT2 using fluoro-lysine sirtuin 2 deacetylase substrate after 60 mins by fluorimetrc method
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 0.5nM
Assay Description:
Inhibition of HDAC1 (unknown origin) using Ac-peptide-AMC as substrate incubated for 1 hr by fluorescence method
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 0.600nM
Assay Description:
Inhibition of recombinant human full-length C-terminal FLAG-tagged HDAC1 expressed in baculovirus expression system using Ac-peptide-AMC as substrate...
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Histone deacetylase 3
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 0.751nM
Assay Description:
The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...
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Histone deacetylase
(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 0.830nM
Assay Description:
Inhibition of HDAC in human HeLa cell nuclear extract using Ac-Leu-Gly-Lys (Ac)-AMC as substrate after 30 mins by fluorescence assay
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 1nM
Assay Description:
Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyw...
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 1nM
Assay Description:
Inhibition of human recombinant HDAC1 using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 1nM
pH: 7.4 T: 2°C
Assay Description:
Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 1.30nM
Assay Description:
Inhibition of full length C-terminal His/FLAG-tagged human recombinant HDAC1 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC ...
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Target Info
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 1.40nM
Assay Description:
Inhibition of HDAC1 (unknown origin)
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Histone deacetylase 3
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 1.5nM
Assay Description:
Inhibition of HDAC3 (unknown origin)
More data for this Ligand-Target Pair
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Target
Histone deacetylase 11
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 1.60nM
Assay Description:
Inhibition of HDAC11 (unknown origin)
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 1.61nM
Assay Description:
The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...
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Target
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)
(Homo sapiens (Human))
Ocean University Of China
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 1.70nM
Assay Description:
Inhibition of recombinant human C-terminal GST/His-tagged HDAC3 (1 to 428 residues) co-expressed with human N-terminal GST-tagged NCOR2 (395 to 489 r...
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Target
Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 1.77nM
Assay Description:
The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...
More data for this Ligand-Target Pair
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Target
Histone deacetylase
(Plasmodium falciparum (isolate 3D7))
Harvard Medical School
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 1.80nM
pH: 7.5 T: 2°C
Assay Description:
Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 1.80nM
Assay Description:
Inhibition of recombinant human HDAC1 using Boc-Lys(acetyl)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured aft...
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 1.80nM
Assay Description:
Inhibition of recombinant human HDAC1 using Boc-Lys(acetyl)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured aft...
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)
(Homo sapiens (Human))
Ocean University Of China
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 1.90nM
Assay Description:
Inhibition of recombinant human C-terminal GST/His-tagged HDAC3 (1 to 428 residues) co-expressed with human N-terminal GST-tagged NCOR2 (395 to 489 r...
More data for this Ligand-Target Pair
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Target
Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 2nM
Assay Description:
Inhibition of human recombinant HDAC6 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled acetylat...
More data for this Ligand-Target Pair
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Target
Polyamine deacetylase HDAC10
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 2nM
Assay Description:
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.
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Histone deacetylase 2
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 2nM
Assay Description:
Inhibition full length human recombinant HDAC2 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxyfluorescein (FAM)-labeled...
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 2
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 2nM
pH: 7.4 T: 2°C
Assay Description:
Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 2nM
pH: 7.4 T: 2°C
Assay Description:
Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Histone deacetylase 3
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 2nM
pH: 7.4 T: 2°C
Assay Description:
Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...
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Histone deacetylase 3
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 2nM
Assay Description:
In vitro inhibition of human dihydrofolate reductase
More data for this Ligand-Target Pair
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Target
Histone deacetylase 3
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 2nM
Assay Description:
Inhibition full length human recombinant HDAC3 expressed in baculovirus using carboxyfluorescein (FAM)-labeled acetylated/ trifluoroacetylated peptid...
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 3
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 2nM
Assay Description:
Inhibition of recombinant HDAC3 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 2.10nM
Assay Description:
Inhibition of recombinant human HDAC1 using Boc-Lys(acetyl)-AMC as substrate preincubated for 60 mins followed by substrate addition and measured aft...
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)
(Homo sapiens (Human))
Ocean University Of China
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 2.10nM
Assay Description:
Inhibition of recombinant human C-terminal GST/His-tagged HDAC3 (1 to 428 residues) co-expressed with human N-terminal GST-tagged NCOR2 (395 to 489 r...
More data for this Ligand-Target Pair
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Target
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)
(Homo sapiens (Human))
Ocean University Of China
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 2.10nM
Assay Description:
Inhibition of recombinant human C-terminal GST/His-tagged HDAC3 (1 to 428 residues) co-expressed with human N-terminal GST-tagged NCOR2 (395 to 489 r...
More data for this Ligand-Target Pair
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Target
Polyamine deacetylase HDAC10
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 2.10nM
Assay Description:
Inhibition of HDAC10 (unknown origin)
More data for this Ligand-Target Pair
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Histone deacetylase
(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 2.10nM
Assay Description:
Inhibition of HDAC (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
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antibodypedia
antibodypedia
antibodypedia
antibodypedia
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antibodypedia
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antibodypedia
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antibodypedia
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Target
Histone deacetylase 3
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 2.10nM
Assay Description:
Inhibition of recombinant HDAC3 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 3
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.10nM
Assay Description:
Inhibition of recombinant HDAC3 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 2.10nM
Assay Description:
Inhibition of recombinant human HDAC1 using Boc-Lys(acetyl)-AMC as substrate preincubated for 90 mins followed by substrate addition and measured aft...
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Histone deacetylase 3
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 2.10nM
Assay Description:
Inhibition of HDAC3 (unknown origin) expressed in HEK293 cells using [3H]acetylated human histone H4 peptide as substrate by scintillation counting
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)
(Homo sapiens (Human))
Ocean University Of China
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 2.10nM
Assay Description:
Inhibition of recombinant human C-terminal GST/His-tagged HDAC3 (1 to 428 residues) co-expressed with human N-terminal GST-tagged NCOR2 (395 to 489 r...
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 3
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 2.10nM
Assay Description:
Inhibition of recombinant HDAC3 (unknown origin)
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Target
Polyamine deacetylase HDAC10
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 2.30nM
Assay Description:
Inhibition of human recombinant HDAC10 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assay
More data for this Ligand-Target Pair
Target Info
NCI pathway
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Target
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)
(Homo sapiens (Human))
Ocean University Of China
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 2.30nM
Assay Description:
Inhibition of full length C-terminal His-tagged human recombinant HDAC3/NCOR2 (395 to 489 residues) expressed in baculovirus infected insect Sf9 cell...
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 2.5nM
Assay Description:
Inhibition of recombinant HDAC1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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KEGG
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.5nM
Assay Description:
Inhibition of recombinant HDAC1 (unknown origin) using Boc-Lys(acetyl)-AMC as substrate preincubated for 1 hr followed by substrate addition and meas...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 2.5nM
Assay Description:
Inhibition of recombinant HDAC1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 2.5nM
Assay Description:
Inhibition of HDAC6 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 2.5nM
Assay Description:
Inhibition of HDAC1 (unknown origin) expressed in HEK293 cells using [3H]acetylated human histone H4 peptide as substrate by scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 2.5nM
Assay Description:
Inhibition of recombinant HDAC1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 11
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 2.70nM
Assay Description:
Inhibition of human recombinant HDAC11 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assay
More data for this Ligand-Target Pair
Target Info
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Histone deacetylase 2
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 3nM
Assay Description:
Inhibition of recombinant HDAC2 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 3nM
Assay Description:
In vitro inhibition of human dihydrofolate reductase
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 11
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 3nM
Assay Description:
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.
More data for this Ligand-Target Pair
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Target
Histone deacetylase
(Plasmodium falciparum (isolate 3D7))
Harvard Medical School
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 3.30nM
Assay Description:
Inhibition of HDAC1 in Plasmodium falciparum 3D7 nuclear extract using Ac-RGK(Ac)-AMC fluorogenic peptide as substrate preincubated for 1 hr followed...
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Target
Histone deacetylase 2
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 3.30nM
Assay Description:
Inhibition of full length human recombinant HDAC2 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC as substrate assessed as re...
More data for this Ligand-Target Pair
Target Info
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Target
Polyamine deacetylase HDAC10
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 4nM
Assay Description:
Inhibition of recombinant HDAC10 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis
More data for this Ligand-Target Pair
Target Info
NCI pathway
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Target
Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 4nM
Assay Description:
Inhibition of human recombinant HDAC6 using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
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KEGG
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Target
Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.20nM
Assay Description:
Inhibition of full length human recombinant HDAC6 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC as substrate assessed as re...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
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Target
Polyamine deacetylase HDAC10
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 4.5nM
Assay Description:
Inhibition of human recombinant HDAC10 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC as substrate assessed as release of AM...
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Histone deacetylase 8
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 4.90nM
Assay Description:
Inhibition of full length C-terminal His-tagged human recombinant HDAC8 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC as su...
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Histone deacetylase 2
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 4.97nM
Assay Description:
The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...
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Target
Histone deacetylase 8
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 5nM
Assay Description:
Inhibition of human recombinant HDAC8 using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis
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Bromodomain-containing protein 4
(Homo sapiens (Human))
Sichuan University and Collaborative Innovation Center
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 5nM
Assay Description:
Inhibition of BRD4 (unknown origin)
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Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 5.60nM
Assay Description:
Inhibition of HDAC6 (unknown origin) using Ac-peptide-AMC as substrate incubated for 1 hr by fluorescence method
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Histone deacetylase 9
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 5.70nM
Assay Description:
Inhibition of recombinant HDAC9 (unknown origin)
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Target
Histone deacetylase 9
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 5.70nM
Assay Description:
Inhibition of human recombinant HDAC9 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assay
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Histone deacetylase 3
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 5.80nM
Assay Description:
Inhibition of recombinant His6/GST-tagged human HDAC3 expressed in baculovirus infected High5 insect cells using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC a...
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Histone deacetylase 9
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 6nM
Assay Description:
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.
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Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 6.10nM
Assay Description:
Inhibition of recombinant His6/GST-tagged human HDAC6 expressed in baculovirus infected High5 insect cells using Boc-Lys(epsion-acetyl)-AMC as substr...
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Histone deacetylase
(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 6.20nM
Assay Description:
Inhibition of HDAC in human CAL27 cells using Boc-Lys(epsilon-Ac)-AMC as substrate preincubated for 18 hrs followed by substrate addition and further...
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Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 6.80nM
Assay Description:
Inhibition of full length recombinant HDAC1 using Fluor de Lys as substrate by fluorescence assay
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Histone deacetylase 2
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 6.80nM
Assay Description:
Inhibition of HDAC2 (unknown origin)
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Target
Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 7nM
Assay Description:
Inhibition of recombinant His6/GST-tagged human HDAC1 expressed in baculovirus infected High5 insect cells using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC a...
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase
(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 7.70nM
Assay Description:
Inhibition of HDAC in human A2780 cells using Boc-Lys(epsilon-Ac)-AMC as substrate preincubated for 18 hrs followed by substrate addition and further...
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Target
Histone deacetylase 5
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 7.80nM
Assay Description:
Inhibition of recombinant HDAC5 (unknown origin)
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Target
Histone deacetylase 5
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 7.80nM
Assay Description:
Inhibition of human recombinant HDAC5 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assay
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Target
Histone deacetylase 5
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 8nM
Assay Description:
Tested in vitro for antagonist activity against H3 receptor of guinea pig jejunum.
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Histone deacetylase 7
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 8.20nM
Assay Description:
Inhibition of HDAC7 (unknown origin)
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Target
Polyamine deacetylase HDAC10
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 10nM
Assay Description:
Inhibition of recombinant human His6/GST-tagged HDAC10 expressed in baculovirus infected High5 insect cells using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC ...
More data for this Ligand-Target Pair
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Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 11nM
Assay Description:
Partial affinity towards Alpha-1 adrenergic receptor was assessed on rat aortic strips
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Target
Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 11nM
Assay Description:
Inhibition of recombinant HDAC6 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 11nM
Assay Description:
Inhibition of HDAC6 (unknown origin) expressed in HEK293 cells using [3H]acetylated human histone H4 peptide as substrate by scintillation counting
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Target
Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 11nM
Assay Description:
Inhibition of recombinant HDAC6 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 11nM
Assay Description:
Inhibition of recombinant HDAC6 (unknown origin) using Boc-Lys(acetyl)-AMC as substrate preincubated for 1 hr followed by substrate addition and meas...
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 11nM
Assay Description:
Inhibition of recombinant HDAC6 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Polyamine deacetylase HDAC10
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 12.7nM
Assay Description:
The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...
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Histone deacetylase 2
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 13nM
Assay Description:
In vitro inhibition of human dihydrofolate reductase
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Histone deacetylase 2
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 13nM
Assay Description:
Inhibition of recombinant HDAC2 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 2
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 13nM
Assay Description:
Inhibition of recombinant HDAC2 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 2
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Copy SMILES
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Affinity Data
IC50: 13nM
Assay Description:
Inhibition of recombinant human HDAC2 expressed in baculovirus expression system using Boc-Lys(acetyl)-AMC as substrate preincubated for 1 hr followe...
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Histone deacetylase 2
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 13nM
Assay Description:
Inhibition of flag-tagged HDAC2 (unknown origin) expressed in SF21 cells using [3H]acetylated human histone H4 peptide as substrate by scintillation ...
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Histone deacetylase 2
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 13nM
Assay Description:
Inhibition of recombinant HDAC2 (unknown origin)
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Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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IC50: <15nM
Assay Description:
Inhibition of HADC1 (unknown origin)
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Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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IC50: <15nM
Assay Description:
Inhibition of HADC6 (unknown origin)
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Histone deacetylase 3
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: <15nM
Assay Description:
Inhibition of HADC3 (unknown origin)
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Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 15nM
Assay Description:
Inhibition of HDAC1 (unknown origin)
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Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 15nM
Assay Description:
Inhibition of HDAC6 (unknown origin)
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Histone deacetylase 3
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 15nM
Assay Description:
Inhibition of HDAC3 (unknown origin)
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Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 20nM
Assay Description:
Inhibition of human KDAC1 using substrate A after 60 mins by fluorescence assay
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Histone deacetylase 8
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 20nM
Assay Description:
Inhibition of recombinant human His6/GST-tagged HDAC8 expressed in baculovirus infected High5 insect cells using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC a...
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Histone deacetylase 1/2/3/8
(Homo sapiens (Human))
The University Of Sydney
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 22nM
Assay Description:
Inhibition Class 1 histone deacetylase in human HeLa nuclear extracts using Fluor-de- Lys-green substrate by fluorescence assay
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Histone deacetylase 2
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 23nM
Assay Description:
Inhibition of recombinant human His6/GST-tagged HDAC2 expressed in baculovirus infected High5 insect cells using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC a...
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Histone deacetylase 1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 26nM
Assay Description:
Inhibition of human recombinant HDAC1 pre-incubated for 30 mins before substrate addition and measured after 30 mins by fluorescence based assay
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Histone deacetylase 4
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 27nM
Assay Description:
Inhibition of HDAC4 (unknown origin)
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Histone deacetylase
(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 30nM
Assay Description:
Inhibition of HDAC in human HeLa cells using Fluor de Lys as substrate by fluorescence assay
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Histone deacetylase 8
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 51.9nM
Assay Description:
The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...
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Histone deacetylase 3
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 60nM
Assay Description:
Inhibition of human KDAC3 using FITC-labeled p53 acetylated peptide as substrate after 60 mins by fluorescence assay
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Histone deacetylase 5
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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IC50: 92nM
Assay Description:
Inhibition of N-terminal GST-tagged full length human recombinant HDAC5 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxy...
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Histone deacetylase 5
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 92nM
pH: 7.4 T: 2°C
Assay Description:
Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...
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Histone deacetylase 11
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 121nM
Assay Description:
Inhibition of recombinant human His6/GST-tagged HDAC11 expressed in baculovirus infected High5 insect cells using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC ...
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Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 124nM
Assay Description:
Inhibition of HDAC6 (unknown origin)
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Target
Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 130nM
Assay Description:
Inhibition of human KDAC6 using FITC-labeled histone H4 acetylated peptide as substrate after 60 mins by fluorescence assay
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Histone deacetylase 2
(Homo sapiens (Human))
St. Jude Children'S Research Hospital
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 136nM
Assay Description:
Inhibition of human recombinant HDAC2 pre-incubated for 30 mins before substrate addition and measured after 30 mins by fluorescence based assay
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Histone deacetylase 5
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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IC50: 166nM
Assay Description:
The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...
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Target
Histone deacetylase 5
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 190nM
Assay Description:
Inhibition of human recombinant HDAC5 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC as substrate assessed as release of AMC...
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Histone deacetylase 5
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 190nM
Assay Description:
Inhibition of recombinant HDAC5 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis
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Target
Histone deacetylase 5
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 196nM
Assay Description:
Inhibition of HDAC5 (unknown origin)
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Histone deacetylase 4
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 200nM
Assay Description:
Inhibition of HDAC4 (unknown origin) expressed in HEK293 cells using [3H]acetylated human histone H4 peptide as substrate by scintillation counting
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Histone deacetylase 4
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 203nM
Assay Description:
Tested in vitro for antagonist activity against H3 receptor of guinea pig jejunum.
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Target
Histone deacetylase 4
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 203nM
Assay Description:
Inhibition of human recombinant HDAC4 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assay
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Target
Histone deacetylase 4
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 203nM
Assay Description:
Inhibition of recombinant HDAC4 (unknown origin)
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Histone deacetylase 8
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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IC50: 231nM
Assay Description:
Inhibition of C-terminal His-tagged full length human recombinant HDAC8 expressed in baculovirus coexpressed in fall armyworm Sf9 cells using carboxy...
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Target
Histone deacetylase 8
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 231nM
pH: 7.4 T: 2°C
Assay Description:
Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...
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Target
Histone deacetylase 8
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 277nM
Assay Description:
Inhibition of recombinant HDAC8 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 8
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 277nM
Assay Description:
In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.
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Target
Histone deacetylase 8
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 277nM
Assay Description:
Inhibition of human recombinant HDAC8 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assay
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 8
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 280nM
Assay Description:
Inhibition of his-strep-tagged HDAC8 (unknown origin) expressed in SF9 cells using [3H]acetylated human histone H4 peptide as substrate by scintillat...
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Target
Histone deacetylase 5
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 290nM
Assay Description:
Inhibition of HDAC5 (unknown origin) using Ac-peptide as substrate preincubated for 15 mins followed by substrate addition by fluorescence assay
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Histone deacetylase 4
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 338nM
Assay Description:
Inhibition of recombinant HDAC4 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis
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Target
Histone deacetylase 4
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 338nM
Assay Description:
Inhibition of N-terminal GST/C-terminal His-tagged human recombinant HDAC4 (627 to 1084 residues) expressed in baculovirus infected insect Sf9 cells ...
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Target Info
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Target
Histone deacetylase 4
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 373nM
pH: 7.4 T: 2°C
Assay Description:
Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...
More data for this Ligand-Target Pair
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Target
Histone deacetylase 4
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 373nM
Assay Description:
Inhibition of N-terminal GST-tagged and C-terminal His-tagged human recombinant HDAC4 (627 to 1084 residues ) expressed in baculovirus coexpressed in...
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Target
Histone deacetylase 8
(Schistosoma mansoni)
Washington University
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 450nM
Assay Description:
Inhibition of Schistosoma mansoni KDAC8 using (FAM)-labeled peptide as substrate after 60 mins by microfluidic assay
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Target
Histone deacetylase 4
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 480nM
Assay Description:
Inhibition of human recombinant HDAC4 using Boc-Lys-(epsilon-Tfa)-AMC fluorogenic substrate incubated for 90 mins by fluorescence based assay
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Target
Histone deacetylase 7
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 531nM
Assay Description:
Inhibition of human recombinant HDAC7 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assay
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 7
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 531nM
Assay Description:
Inhibition of recombinant HDAC7 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 7
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 531nM
Assay Description:
Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus
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Target
Histone deacetylase 8
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 550nM
Assay Description:
Inhibition of HDAC8 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 8
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 550nM
Assay Description:
Inhibition of HADC8 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 9
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 888nM
Assay Description:
Inhibition of C-terminal His-tagged human recombinant HDAC9 (604 to 1066 residues) expressed in baculovirus infected insect Sf9 cells using Ac-peptid...
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Target
Histone deacetylase 9
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 888nM
Assay Description:
Inhibition of recombinant HDAC9 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis
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Target
Histone deacetylase 9
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 922nM
Assay Description:
Inhibition of HDAC9 (unknown origin)
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Target
Histone deacetylase 9
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 1.04E+3nM
Assay Description:
The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...
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Target
Histone deacetylase 4
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 1.55E+3nM
Assay Description:
The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...
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Target
Histone deacetylase 11
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 1.67E+3nM
Assay Description:
The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...
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Target
Histone deacetylase 8
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 1.78E+3nM
Assay Description:
Inhibition of human KDAC8 after 60 mins by fluorescence assay
More data for this Ligand-Target Pair
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Target
Histone deacetylase 8
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 1.86E+3nM
Assay Description:
Inhibition of HDAC8 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 9
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 2.68E+3nM
pH: 7.4 T: 2°C
Assay Description:
Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...
More data for this Ligand-Target Pair
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Target
Histone deacetylase 9
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 2.68E+3nM
Assay Description:
Inhibition of C-terminal His-tagged human recombinant HDAC9 (604 to 1066 residues) expressed in baculovirus coexpressed in fall armyworm Sf9 cells us...
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Target
Histone deacetylase 7
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 2.83E+3nM
Assay Description:
Inhibition of N-terminal GST-tagged human recombinant HDAC7 (518 to end residues) expressed in baculovirus coexpressed in fall armyworm Sf9 cells usi...
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 7
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 2.83E+3nM
pH: 7.4 T: 2°C
Assay Description:
Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Histone deacetylase 7
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 3.68E+3nM
Assay Description:
The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...
More data for this Ligand-Target Pair
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Target
Histone deacetylase 11
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 4.11E+3nM
Assay Description:
Inhibition of recombinant HDAC11 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis
More data for this Ligand-Target Pair
Target Info
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Target
Histone deacetylase 11
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 4.11E+3nM
Assay Description:
Inhibition of full length human recombinant HDAC11 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC as substrate assessed as r...
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Target
Histone deacetylase 7
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 4.35E+3nM
Assay Description:
Inhibition of recombinant HDAC7 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis
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Target
Histone deacetylase 7
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 4.35E+3nM
Assay Description:
Inhibition of N-terminal GST-tagged human recombinant HDAC7 (518 to end residues) expressed in baculovirus infected insect Sf9 cells using Ac-peptide...
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Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human p110beta expressed in baculovirus infected insect Sf9 cells incubated for 1 hr by ADP-gloreagen assay
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Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of His-tagged full length recombinant human p110gamma expressed in baculovirus expression system incubated for 1 hr by ADP-gloreagen assay
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Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
East China University Of Science And Technology
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human LTA4H aminopeptidase activity expressed in Escherichia coli BL21 (DE3) pLysS assessed as formation of p-NA from Ala-p...
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Target
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human))
West China Hospital Of Sichuan University
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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IC50: >1.00E+4nM
Assay Description:
Inhibition of N-terminal His6-tagged recombinant full-length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...
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Target
Leukotriene A-4 hydrolase
(Homo sapiens (Human))
East China University Of Science And Technology
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human LTA4H Epoxide Hydrolase expressed in Escherichia coli BL21 (DE3) pLysS preincubated for 10 mins followed by addition ...
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Target
Histone deacetylase 4
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: 1.04E+4nM
Assay Description:
Inhibition of recombinant human His6/GST-tagged HDAC4 expressed in baculovirus infected High5 insect cells using Ac-Leu-Gly-Lys(Tfa)-AMC as substrate...
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Target
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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IC50: >2.00E+4nM
Assay Description:
Inhibition of recombinant human N-terminal GST-tagged SIRT1 expressed in Escherichia coli using Ac-Arg-His-Lys-Lys(Ac)-AMC as susbtrate after 1 hr by...
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Histone deacetylase 5
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of recombinant N-terminal GST-tagged full length human HDAC5 expressed in baculovirus infected Sf9 cells using Ac-Leu-Gly-Lys(Tfa)-AMC as ...
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NAD-dependent protein deacetylase sirtuin-2
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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IC50: >2.00E+4nM
Assay Description:
Inhibition of recombinant human N-terminal GST-tagged SIRT2 expressed in Escherichia coli using Ac-Arg-His-Lys-Lys(Ac)-AMC as susbtrate after 2 hrs b...
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Histone deacetylase 9
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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IC50: >2.00E+4nM
Assay Description:
Inhibition of recombinant human C-terminal His-tagged HDAC9 (604 to 1066 residues) expressed in baculovirus infected Sf9 cells using Ac-Leu-Gly-Lys(T...
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Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
(Homo sapiens (Human))
Nestle Skin Health R&D
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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IC50: >2.00E+4nM
Assay Description:
Inhibition of recombinant human N-terminal His-tagged SIRT3 expressed in Escherichia coli using Ac-Arg-His-Lys-Lys(Ac)-AMC as susbtrate after 2 hrs b...
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Histone deacetylase 7
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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Affinity Data
IC50: >2.00E+4nM
Assay Description:
Inhibition of human N-terminal GST-tagged HDAC7 (518 to end residues) expressed in baculovirus infected Sf9 cells using Ac-Leu-Gly-Lys(Tfa)-AMC as su...
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Histone deacetylase 6
(Homo sapiens (Human))
S*Bio
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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EC50: 151nM
Assay Description:
Inhibition of HDAC6 in human A2780S cells assessed as tubulin acetylation incubated for 6 hrs by cytoblot assay
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Target
Protein Tat
(Human immunodeficiency virus type 1 (isolate HXB2 ...)
The Walter And Eliza Hall Institute For Medical Research
Curated by
ChEMBL
Ligand
BDBM29589
(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
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EC50: 130nM
Assay Description:
Activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells harboring LTR driven GFP reporter co-expressing CMV driven RFP reporter assessed as...
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