Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 14 hits in this display   

TargetCyclin-C(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL

LigandBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)Copy SMILESCopy InChI

Affinity DataIC50:  4nMAssay Description:Inhibition of CDK8/Cyclin-C (unknown origin) in presence of [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sid

In DepthDetails ArticlePubMed
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TargetCyclin-C(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL

LigandBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)Copy SMILESCopy InChI

Affinity DataIC50:  4.40nMAssay Description:Inhibition of CDK8/Cyclin C (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchasePC cidPC sid

In DepthDetails PubMed
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TargetCyclin-dependent kinase 8(Homo sapiens (Human))TBA

LigandBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)Copy SMILESCopy InChI

Affinity DataIC50:  4.40nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sid

In DepthDetails PubMed
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TargetCyclin-dependent kinase 8(Homo sapiens (Human))TBA

LigandBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)Copy SMILESCopy InChI

Affinity DataIC50:  4.40nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sid

In DepthDetails ArticlePubMed
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TargetCyclin-dependent kinase 8(Homo sapiens (Human))TBA

LigandBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)Copy SMILESCopy InChI

Affinity DataIC50:  4.40nMAssay Description:Inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sid

In DepthDetails ArticlePubMed
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TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))TBA

LigandBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)Copy SMILESCopy InChI

Affinity DataIC50:  10nMAssay Description:Inhibition of CDK19/Cyclin C (unknown origin)More data for this Ligand-Target Pair

Target InfoMMDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankGoogleScholar

Ligand InfoPurchasePC cidPC sid

In DepthDetails PubMed
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TargetCyclin-dependent kinase 19(Homo sapiens (Human))
Shaoxing University

Curated by ChEMBL

LigandBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)Copy SMILESCopy InChI

Affinity DataIC50:  10nMAssay Description:Inhibition of CDK19 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sid

In DepthDetails ArticlePubMed
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TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL

LigandBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)Copy SMILESCopy InChI

Affinity DataIC50:  10nMAssay Description:Inhibition of CDK19/Cyclin-C (unknown origin) in presence of [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCyclin-dependent kinase 19(Homo sapiens (Human))
Shaoxing University

Curated by ChEMBL

LigandBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)Copy SMILESCopy InChI

Affinity DataIC50:  10nMAssay Description:Inhibition of CDK19 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sid

In DepthDetails ArticlePubMed
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TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL

LigandBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)Copy SMILESCopy InChI

Affinity DataIC50:  10nMAssay Description:Inhibition of CDK19/Cyclin C (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sid

In DepthDetails PubMed
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TargetCyclin-dependent kinase 8(Homo sapiens (Human))TBA

LigandBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)Copy SMILESCopy InChI

Affinity DataIC50:  37nMAssay Description:Inhibition of CDK8 (unknown origin) incubated in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sid

In DepthDetails PubMed
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TargetCyclin-dependent kinase 9(Homo sapiens (Human))
University Of South Australia

Curated by ChEMBL

LigandBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)Copy SMILESCopy InChI

Affinity DataIC50:  1.07E+3nMAssay Description:Inhibition of CDK9 (unknown origin) in presence of [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCyclin-dependent kinase 8(Homo sapiens (Human))TBA

LigandBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)Copy SMILESCopy InChI

Affinity DataIC50:  7.40E+3nMAssay Description:Inhibition of CDK8 in human HCT-116 cells transfected with TOPFlash luciferase reporter plasmid assessed as reduction in TCF/LEF transcriptional acti...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sid

In DepthDetails PubMed
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TargetCyclin-dependent kinase 8/19(Homo sapiens (Human))
Lu License

US Patent

LigandBDBM50459995(CHEMBL4225966 | US11471446, Compound DBA-10)Copy SMILESCopy InChI

Affinity DataEC50:  20nMAssay Description:The results presented in Example 3 and in particular the KinomeScan indicate that the activity of DBA-7 in our proliferation assay was due to inhibit...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sid

In DepthDetails US Patent
Copy BDB DOI