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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetProthrombin(Homo sapiens (Human))
Omeros

US Patent
LigandPNGBDBM32909((4-methyl-2-oxidanylidene-chromen-7-yl) furan-2-ca...)
Affinity DataKi: <1.00E+3nMAssay Description:The thrombin assay utilizes a fluorogenic peptide substrate (Boc-VPR-AMC (R&D Systems) and was run at room temperature in an assay buffer containing ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM32909((4-methyl-2-oxidanylidene-chromen-7-yl) furan-2-ca...)
Affinity DataKi: <1.00E+3nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM32909((4-methyl-2-oxidanylidene-chromen-7-yl) furan-2-ca...)
Affinity DataIC50:  49.7nMpH: 7.4 T: 2°CAssay Description:Factor XIa (0.23 ug/mL) was incubated with Boc-Glu-Ala-Arg-AMC substrate (15 uM) in 10 uL of assay buffer for 2 hr at room temperature. Read fluoresc...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProthrombin(Homo sapiens (Human))
Omeros

US Patent
LigandPNGBDBM32909((4-methyl-2-oxidanylidene-chromen-7-yl) furan-2-ca...)
Affinity DataIC50:  949nMpH: 7.5 T: 2°CAssay Description:HTS was performed using 217,350 compounds of the MLSCN library individually plated into 10ul 1536 compound plates at a concentration of 2.5 mM each, ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
Target3C-like protease(Avian infectious bronchitis virus)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM32909((4-methyl-2-oxidanylidene-chromen-7-yl) furan-2-ca...)
Affinity DataIC50:  3.34E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCoagulation factor XII(Homo sapiens (Human))
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM32909((4-methyl-2-oxidanylidene-chromen-7-yl) furan-2-ca...)
Affinity DataIC50: >5.00E+4nMAssay Description:Molecular Library Screening Center Network (MLSCN) Penn Center for Molecular Discovery (PCMD) Assay Provider: Scott L. Diamond, University of Pennsy...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay