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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Cathepsin B
(Homo sapiens (Human))
Novartis Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50107650
(CHEMBL138661 | N-Cyanomethyl-3-(3,5-dimethyl-pheny...)
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Affinity Data
IC50: 11.9nM
Assay Description:
Inhibitiory activity against recombinant human cathepsin B (cat B) expressed in baculovirus.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Cathepsin B
(Homo sapiens (Human))
Novartis Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50269860
(CHEMBL477531 | N-(cyanomethyl)-3-(3,5-dimethylphen...)
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Copy InChI
Affinity Data
IC50: 40nM
Assay Description:
Inhibition of human recombinant cathepsin B after 10 mins
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Procathepsin L
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50269860
(CHEMBL477531 | N-(cyanomethyl)-3-(3,5-dimethylphen...)
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Affinity Data
IC50: 90nM
Assay Description:
Inhibition of human recombinant cathepsin L after 10 mins
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cathepsin S
(Homo sapiens (Human))
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50269860
(CHEMBL477531 | N-(cyanomethyl)-3-(3,5-dimethylphen...)
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Copy InChI
Affinity Data
IC50: 470nM
Assay Description:
Inhibition of human recombinant cathepsin S after 10 mins
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Neutrophil elastase
(Mus musculus)
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50269860
(CHEMBL477531 | N-(cyanomethyl)-3-(3,5-dimethylphen...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibition of neutrophil elastase activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrs
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cathepsin G
(Mus musculus)
Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50269860
(CHEMBL477531 | N-(cyanomethyl)-3-(3,5-dimethylphen...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >5.00E+4nM
Assay Description:
Inhibition of cathepsin G activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrs
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI