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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
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Target
D-3-phosphoglycerate dehydrogenase
(Homo sapiens (Human))
Whitehead Institute For Biomedical Research
Ligand
BDBM195605
(NCT-502 | US11225469, Compound 72)
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Affinity Data
IC50: 3.70E+3nM
pH: 8.0 T: 2°C
Assay Description:
PHGDH assay buffer contained 50 mM TEA pH 8.0, 10 mM MgCl2, 0.05% BSA, and 0.01% Tween-20. PHGDH enzyme buffer consisted of assay buffer with 20 nM P...
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Target Info
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PubMed
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Target
D-3-phosphoglycerate dehydrogenase
(Homo sapiens (Human))
Whitehead Institute For Biomedical Research
Ligand
BDBM195605
(NCT-502 | US11225469, Compound 72)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.70E+3nM
Assay Description:
Inhibition of human liver N-terminal His6-tagged PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3 -phosphoglycerate as substarte measur...
More data for this Ligand-Target Pair
Target Info
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UniProtKB/SwissProt
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PC cid
PC sid
In Depth
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Article
PubMed
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Target
D-3-phosphoglycerate dehydrogenase
(Homo sapiens (Human))
Whitehead Institute For Biomedical Research
Ligand
BDBM195605
(NCT-502 | US11225469, Compound 72)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.70E+3nM
Assay Description:
Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
D-3-phosphoglycerate dehydrogenase
(Homo sapiens (Human))
Whitehead Institute For Biomedical Research
Ligand
BDBM195605
(NCT-502 | US11225469, Compound 72)
Copy SMILES
Copy InChI
Affinity Data
IC50: <5.00E+3nM
Assay Description:
PHGDH assay buffer contained 50 mM TEA pH 8.0, 10 mM MgCl2, 0.05% BSA, and 0.01% Tween-20. PHGDH enzyme buffer consisted of assay buffer with 20 nM P...
More data for this Ligand-Target Pair
Target Info
PDB
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UniProtKB/SwissProt
GoogleScholar
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PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
D-3-phosphoglycerate dehydrogenase
(Homo sapiens (Human))
Whitehead Institute For Biomedical Research
Ligand
BDBM195605
(NCT-502 | US11225469, Compound 72)
Copy SMILES
Copy InChI
Affinity Data
EC50: 1.75E+4nM
Assay Description:
Inhibition of PHGDH in human MDA-MB-468 cells assessed as decrease in serine flux
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
PC cid
PC sid
In Depth
Details
Article
PubMed
Copy BDB DOI