Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 19 hits in this display   

TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50524102(CHEMBL4542281)Copy SMILESCopy InChI

Affinity DataIC50:  6.30nMAssay Description:Inhibition of [3H]MK0591 binding to human FLAP expressed in human COS7 cell membranes measured after 60 to 80 mins by microbeta scintillation countin...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPurchasePC cidPC sid

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TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50524102(CHEMBL4542281)Copy SMILESCopy InChI

Affinity DataIC50:  2.30E+3nMAssay Description:Substrate activity at recombinant human OATP1B1 expressed in HEK293 cells assessed as reduction in pivastatin uptakeMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Ligand InfoPurchasePC cidPC sid

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TargetCytochrome P450 2D6(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50524102(CHEMBL4542281)Copy SMILESCopy InChI

Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human CYP2D6 expressed in Escherichia coli using MAMC as substrate by fluorescence assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Ligand InfoPurchasePC cidPC sid

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TargetCytochrome P450 2C9(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50524102(CHEMBL4542281)Copy SMILESCopy InChI

Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human CYP2C9 expressed in Escherichia coli using 7MFC as substrate by fluorescence assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPurchasePC cidPC sid

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TargetCytochrome P450 1A2(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50524102(CHEMBL4542281)Copy SMILESCopy InChI

Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human CYP1A2 expressed in Escherichia coli using CEC as substrate by fluorescence assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPurchasePC cidPC sid

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TargetCytochrome P450 3A4(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50524102(CHEMBL4542281)Copy SMILESCopy InChI

Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human CYP3A4 expressed in Escherichia coli using BFC as substrate by fluorescence assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sid

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TargetCytochrome P450 2C8(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50524102(CHEMBL4542281)Copy SMILESCopy InChI

Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human CYP2C8 expressed in Escherichia coli using luciferin-ME as substrate by fluorescence assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPurchasePC cidPC sid

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TargetCytochrome P450 2C19(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50524102(CHEMBL4542281)Copy SMILESCopy InChI

Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human CYP2C19 expressed in Escherichia coli using CEC as substrate by fluorescence assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPurchasePC cidPC sid

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TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50524102(CHEMBL4542281)Copy SMILESCopy InChI

Affinity DataIC50: >3.20E+4nMAssay Description:Inhibition of human Cav3.2 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Ligand InfoPurchasePC cidPC sid

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TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50524102(CHEMBL4542281)Copy SMILESCopy InChI

Affinity DataIC50: >3.20E+4nMAssay Description:Inhibition of human Kv1.5 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Ligand InfoPurchasePC cidPC sid

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TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50524102(CHEMBL4542281)Copy SMILESCopy InChI

Affinity DataIC50: >3.20E+4nMAssay Description:Inhibition of human HCN4 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPurchasePC cidPC sid

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TargetKv channel-interacting protein 2(Homo sapiens)
TBA

Curated by ChEMBL

LigandBDBM50524102(CHEMBL4542281)Copy SMILESCopy InChI

Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of human KChip2.2 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Ligand InfoPurchasePC cidPC sid

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TargetPotassium voltage-gated channel subfamily D member 3(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50524102(CHEMBL4542281)Copy SMILESCopy InChI

Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of human Kv4.3 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPurchasePC cidPC sid

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TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50524102(CHEMBL4542281)Copy SMILESCopy InChI

Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of human ERG by Ion-work assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPurchasePC cidPC sid

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TargetPotassium voltage-gated channel subfamily E member 1(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50524102(CHEMBL4542281)Copy SMILESCopy InChI

Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of human KCNE1 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPurchasePC cidPC sid

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TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50524102(CHEMBL4542281)Copy SMILESCopy InChI

Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of human NaV1.5 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPurchasePC cidPC sid

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TargetPotassium voltage-gated channel subfamily KQT member 1(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50524102(CHEMBL4542281)Copy SMILESCopy InChI

Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of human Kv7.1 by Ion-work electrophysiology assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sid

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TargetATP-binding cassette sub-family C member 2(Rattus norvegicus)
TBA

Curated by ChEMBL

LigandBDBM50524102(CHEMBL4542281)Copy SMILESCopy InChI

Affinity DataIC50:  7.40E+4nMAssay Description:Inhibition of Sprague-Dawley rat Mrp2 expressed in baculovirus infected Sf21 insect cell vesicles assessed as reduction in CDF uptake by fluorescence...More data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
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Ligand InfoPurchasePC cidPC sid

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TargetBile salt export pump(Homo sapiens (Human))
TBA

Curated by ChEMBL

LigandBDBM50524102(CHEMBL4542281)Copy SMILESCopy InChI

Affinity DataIC50:  7.40E+4nMAssay Description:Inhibition of recombinant human BSEP expressed in baculovirus infected Sf21 insect cell vesicles assessed as reduction in NBD-taurocholate uptake by ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sid

In DepthDetails ArticlePubMed
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