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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Amine oxidase [flavin-containing] B
(Homo sapiens (Human))
University of Porto
Curated by
ChEMBL
Ligand
BDBM23538
(3-Carboxamide-coumarin deriv., 20 | 6-methyl-2-oxo...)
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Affinity Data
IC50: 15nM
Assay Description:
Inhibition of human recombinant microsomal MAOB expressed in baculovirus infected BTI-TN-5B1- 4 cells using p-tyramine as substrate assessed as decre...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Coagulation factor XII
(Homo sapiens (Human))
University of Namur
Ligand
BDBM23538
(3-Carboxamide-coumarin deriv., 20 | 6-methyl-2-oxo...)
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Affinity Data
IC50: 2.30E+4nM
pH: 7.9 T: 2°C
Assay Description:
After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Plasma kallikrein
(Homo sapiens (Human))
University of Namur
Ligand
BDBM23538
(3-Carboxamide-coumarin deriv., 20 | 6-methyl-2-oxo...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prothrombin
(Homo sapiens (Human))
University of Namur
Ligand
BDBM23538
(3-Carboxamide-coumarin deriv., 20 | 6-methyl-2-oxo...)
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Affinity Data
IC50: >5.00E+4nM
Assay Description:
After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration w...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor X
(Homo sapiens (Human))
University of Namur
Ligand
BDBM23538
(3-Carboxamide-coumarin deriv., 20 | 6-methyl-2-oxo...)
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Affinity Data
Assay Description:
After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Coagulation factor VII
(Homo sapiens (Human))
University of Namur
Ligand
BDBM23538
(3-Carboxamide-coumarin deriv., 20 | 6-methyl-2-oxo...)
Copy SMILES
Copy InChI
Affinity Data
Assay Description:
After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration w...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI