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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 15 hits in this display   

TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50:  6nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50:  22nMAssay Description:Inhibition of TYK2/JAK1 signalling in human PBMC assessed as inhibition of INF-alpha stimulated phosphorylation of STAT3 preincubated for 60 mins fol...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50:  37nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50:  65nMAssay Description:Inhibition of TYK2/JAK1 signalling in human PBMC assessed as inhibition of IL-10 stimulated phosphorylation of STAT3 preincubated for 60 mins followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50:  140nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetJAK3/JAK1(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50:  296nMAssay Description:Inhibition of JAK1/JAK3 signalling in human PBMC assessed as inhibition of IL-21 stimulated phosphorylation of STAT3 preincubated for 60 mins followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50:  299nMAssay Description:Inhibition of JAK2/TYK2 signalling in human PBMC assessed as inhibition of IL-23 stimulated phosphorylation of STAT3 preincubated for 60 mins followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50:  362nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1/JAK2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50:  1.12E+3nMAssay Description:Inhibition of JAK1/JAK2 signalling in human PBMC assessed as inhibition of IL-27 stimulated phosphorylation of STAT3 preincubated for 60 mins followe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2E1(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center Of Biotherapy

Curated by ChEMBL
LigandPNGBDBM50583442(CHEMBL5077096)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP2E1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed