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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
15
hits in this display
Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50014154
(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
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Affinity Data
Ki: 1.5nM
Assay Description:
Antibacterial activity against Escherichia coli DHFR
More data for this Ligand-Target Pair
Target Info
PDB
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Target
5-hydroxytryptamine receptor 3A
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50014154
(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
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Affinity Data
Ki: 1.80nM
Assay Description:
Binding affinity towards 5-hydroxytryptamine 3 receptor by displacement of [3H]2 in Neuroblastoma-Glioma NG-108-15 cells
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Sigma non-opioid intracellular receptor 1
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50014154
(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Binding affinity for Sigma opioid receptor was determined by using [3H](+)-3-(3-hydroxyphenyl)N-1-propyl-piperdine((+)-3-PPP) as radioligand
More data for this Ligand-Target Pair
Target Info
PDB
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Target
Beta-2 adrenergic receptor
(Canis familiaris)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50014154
(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Binding affinity for Beta adrenergic receptor was determined by using [3H]dihydroalprenolol as radioligand
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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Target
Adenosine receptor A2b
(Rattus norvegicus)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50014154
(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Binding affinity for Alpha-2 adrenergic receptor was determined by using [3H]p-aminoclonidine as radioligand
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Article
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Target
Muscarinic acetylcholine receptor M3
(RAT)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50014154
(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Binding affinity for Muscarinic acetylcholine receptor was determined by using [3H]QNB as radioligand
More data for this Ligand-Target Pair
Target Info
PDB
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Article
PubMed
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Target
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50014154
(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 1C receptor was determined by using [3H]- mesulergine as radioligand
More data for this Ligand-Target Pair
Target Info
PDB
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Details
Article
PubMed
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Target
D(1A) dopamine receptor
(Mus musculus (Mouse))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50014154
(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Binding affinity for Dopamine receptor D1 was determined by using [3H]SCH-23390 as radioligand
More data for this Ligand-Target Pair
Target Info
PDB
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50014154
(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Binding affinity for Dopamine receptor D2 was determined by using [3H]spiperone as radioligand
More data for this Ligand-Target Pair
Target Info
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Article
PubMed
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Target
Mu-type opioid receptor
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50014154
(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Binding affinity for Opioid receptor mu 1 was determined by using [3H]naloxone as radioligand
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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Target
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50014154
(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 1D receptor was determined by using [3H]5-HT as radioligand
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Article
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Target
5-hydroxytryptamine receptor 2A
(BOVINE)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50014154
(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 2 receptor was determined by using [3H]ketanserin as radioligand
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
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In Depth
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Target
Alpha-2A adrenergic receptor [16-465]
(Rattus norvegicus (rat))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50014154
(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Binding affinity for Alpha-1 adrenergic receptor was determined by using [3H]prazosin as radioligand
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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Ligand Info
CHEMBL
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In Depth
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Article
PubMed
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Target
5-hydroxytryptamine receptor 1A
(Mus musculus (Mouse))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50014154
(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
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Affinity Data
Ki: >1.00E+3nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 1A receptor was determined by using [3H]8-OH-DPAT as radioligand
More data for this Ligand-Target Pair
Target Info
PDB
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UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
5-hydroxytryptamine receptor 1B
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50014154
(2-(5-Methyl-1H-imidazol-4-ylmethyl)-4-phenyl-thiaz...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >1.00E+3nM
Assay Description:
Binding affinity for 5-hydroxytryptamine 1B receptor was determined by using [3H]5-HT as radioligand
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI