Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 20 hits in this display   

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50207516(CHEMBL3942511)Copy SMILESCopy InChI

Affinity DataIC50:  150nMAssay Description:Displacement of [125I]-RTI-55 from recombinant human DAT expressed in CHO-S cellsMore data for this Ligand-Target Pair

Target InfoNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50207516(CHEMBL3942511)Copy SMILESCopy InChI

Affinity DataIC50:  520nMAssay Description:Displacement of [3H]-Paroxetine from recombinant human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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Target5-hydroxytryptamine receptor 3A(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50207516(CHEMBL3942511)Copy SMILESCopy InChI

Affinity DataIC50:  1.50E+3nMAssay Description:Displacement of [3H] GR-65630 from recombinant human 5-HT3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50207516(CHEMBL3942511)Copy SMILESCopy InChI

Affinity DataIC50:  6.50E+3nMAssay Description:Inhibition of ghrelin receptor (unknown origin) by radioligand binding assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCytochrome P450 2D6(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50207516(CHEMBL3942511)Copy SMILESCopy InChI

Affinity DataIC50:  2.39E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetCytochrome P450 3A4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50207516(CHEMBL3942511)Copy SMILESCopy InChI

Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCytochrome P450 1A2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50207516(CHEMBL3942511)Copy SMILESCopy InChI

Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCytochrome P450 2C9(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50207516(CHEMBL3942511)Copy SMILESCopy InChI

Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50207516(CHEMBL3942511)Copy SMILESCopy InChI

Affinity DataEC50:  550nMAssay Description:Positive allosteric modulation of human M4 receptor expressed in CHO cells co-expressing Gqui5 by calcium mobilization assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50207516(CHEMBL3942511)Copy SMILESCopy InChI

Affinity DataEC50: >3.00E+4nMAssay Description:Displacement of [3H]-N-Methylscopolamine from human M1 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair

Target InfoReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMuscarinic acetylcholine receptor M4(RAT)
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50207516(CHEMBL3942511)Copy SMILESCopy InChI

Affinity DataEC50:  30nMAssay Description:Positive allosteric modulation of rat M4 receptor expressed in CHO cells co-expressing Gqui5 by calcium mobilization assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50207516(CHEMBL3942511)Copy SMILESCopy InChI

Affinity DataEC50: >3.00E+4nMAssay Description:Binding affinity to human M5 receptor by radio-ligand binding assayMore data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMuscarinic acetylcholine receptor M1(RAT)
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50207516(CHEMBL3942511)Copy SMILESCopy InChI

Affinity DataEC50: >3.00E+4nMAssay Description:Binding affinity to rat M1 receptor by radio-ligand binding assayMore data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50207516(CHEMBL3942511)Copy SMILESCopy InChI

Affinity DataEC50: >3.00E+4nMAssay Description:Displacement of [3H]-N-Methylscopolamine from human M2 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMuscarinic acetylcholine receptor M4(RAT)
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50207516(CHEMBL3942511)Copy SMILESCopy InChI

Affinity DataEC50:  30nMAssay Description:Positive allosteric modulation of rat M4 receptor expressed in CHO cells co-expressing Gqui5 by calcium mobilization assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMuscarinic acetylcholine receptor M3(RAT)
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50207516(CHEMBL3942511)Copy SMILESCopy InChI

Affinity DataEC50: >3.00E+4nMAssay Description:Binding affinity to rat M3 receptor by radio-ligand binding assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMuscarinic acetylcholine receptor M2(RAT)
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50207516(CHEMBL3942511)Copy SMILESCopy InChI

Affinity DataEC50: >3.00E+4nMAssay Description:Binding affinity to rat M2 receptor by radio-ligand binding assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMuscarinic acetylcholine receptor M5(RAT)
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50207516(CHEMBL3942511)Copy SMILESCopy InChI

Affinity DataEC50: >3.00E+4nMAssay Description:Binding affinity to rat M5 receptor by radio-ligand binding assayMore data for this Ligand-Target Pair

Target InfoReactome pathwayKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50207516(CHEMBL3942511)Copy SMILESCopy InChI

Affinity DataEC50: >3.00E+4nMAssay Description:Displacement of [3H]-N-Methylscopolamine from human M3 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL

LigandBDBM50207516(CHEMBL3942511)Copy SMILESCopy InChI

Affinity DataEC50:  550nMAssay Description:Positive allosteric modulation of human M4 receptor expressed in CHO cells co-expressing Gqui5 by calcium mobilization assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
DrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI