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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
18
hits in this display
Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
Universite Orleans
Curated by
ChEMBL
Ligand
BDBM50161764
((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
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Affinity Data
Ki: 17nM
Assay Description:
Displacement of [125I]alpha-bungarotoxin from alpha7 nAchR in rat frontal cortices
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
Universite Orleans
Curated by
ChEMBL
Ligand
BDBM50161764
((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
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Affinity Data
Ki: 24nM
Assay Description:
Displacement of [3H]MLA from alpha7 nAChR in Sprague-Dawley rat brain homogenates
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
Universite Orleans
Curated by
ChEMBL
Ligand
BDBM50161764
((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
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Affinity Data
Ki: 24nM
Assay Description:
Displacement of [3H]MLA from alpha-7 nACh receptor in rat brain
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Vu University Amsterdam
Curated by
ChEMBL
Ligand
BDBM50161764
((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
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Affinity Data
Ki: 24.6nM
Assay Description:
Displacement of [3H]-MLA from human alpha7 nAChR expressed in human SH-SY5Y cells
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Vu University Amsterdam
Curated by
ChEMBL
Ligand
BDBM50161764
((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
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Affinity Data
Ki: 26nM
Assay Description:
Agonist activity at alpha7 nAChR (unknown origin)
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Rattus norvegicus (Rat))
Universite Orleans
Curated by
ChEMBL
Ligand
BDBM50161753
(CHEMBL554984 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
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Affinity Data
Ki: 27nM
Assay Description:
Inhibition of methyllycaconitine (MLA) binding to Nicotinic acetylcholine receptor alpha-7 in rat brain homogenates
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Target
5-hydroxytryptamine receptor 3A
(Homo sapiens (Human))
University Of Illinois At Chicago
Curated by
ChEMBL
Ligand
BDBM50161764
((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
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Affinity Data
Ki: 930nM
Assay Description:
Inhibition of 5-HT3 receptor (unknown origin)
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Target
5-hydroxytryptamine receptor 3A/3B/3C/3D/3E
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50161764
((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
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Affinity Data
Ki: 1.66E+3nM
Assay Description:
Binding affinity to 5HT3 receptor
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50161753
(CHEMBL554984 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
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Affinity Data
Ki: 1.66E+3nM
Assay Description:
Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor from rat brain homogenates
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Target
Acetylcholine-binding protein
(Lymnaea stagnalis)
Vu University Amsterdam
Curated by
ChEMBL
Ligand
BDBM50161764
((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
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Affinity Data
Ki: 2.09E+3nM
Assay Description:
Displacement of [3H]epibatidine from Lymnaea stagnalis His6-AChBP expressed in Bac-to-Bac baculovirus expression system
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Target
5-hydroxytryptamine receptor 3A/3B/3C/3D/3E
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50161764
((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
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Affinity Data
Ki: 4.54E+3nM
Assay Description:
Activity at 5HT3 receptor expressed in SHEP1 cells by FLIPR assay
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Target
Soluble acetylcholine receptor
(Aplysia Californica)
Uc San Diego
Ligand
BDBM50161764
((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
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Affinity Data
Ki: 3.30E+4nM ΔG°: -25.1kJ/mole
pH: 7.4 T: 2°C
Assay Description:
Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ul of 0.2 mg/ml an...
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Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50161764
((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
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Affinity Data
IC50: >3.00E+3nM
Assay Description:
Inhibition of CYP2D6
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Target
5-hydroxytryptamine receptor 3A/3B
(Rattus norvegicus)
Pfizer
Curated by
ChEMBL
Ligand
BDBM50161753
(CHEMBL554984 | N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl...)
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Affinity Data
IC50: 4.54E+3nM
Assay Description:
Functional antagonism of rat 5-hydroxytryptamine 3 receptor in cell-based FLIPR assay
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Target
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50161764
((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
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Affinity Data
IC50: >6.00E+4nM
Assay Description:
Inhibition of alpha1beta1gammadelta nAChR expressed in TE671cells by FLIPR assay
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Target
Neuronal acetylcholine receptor subunit alpha-3/beta-4
(Homo sapiens (Human))
Pfizer
Curated by
ChEMBL
Ligand
BDBM50161764
((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
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Affinity Data
IC50: >6.00E+4nM
Assay Description:
Inhibition of alpha3beta4 nAChR expressed in SHSY5Y cells by FLIPR assay
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Target
Acetylcholine-binding protein
(Lymnaea stagnalis)
Vu University Amsterdam
Curated by
ChEMBL
Ligand
BDBM50161764
((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
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Affinity Data
Kd: 3.63E+3nM
Assay Description:
Binding affinity to Lymnaea stagnalis His6-AChBP expressed in Bac-to-Bac baculovirus expression system by surface plasmon resonance biosensor assay
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Target
Neuronal acetylcholine receptor subunit alpha-7
(Homo sapiens (Human))
Vu University Amsterdam
Curated by
ChEMBL
Ligand
BDBM50161764
((R)-4-chloro-N-(quinuclidin-3-yl)benzamide | (R)-4...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 40nM
pH: 7.4 T: 2°C
Assay Description:
Assay Description 2 Assays used to generate Ki or EC50 values. 1) SPA Assay - Quick screen binding assays were performed using 100 ul of 0.2 mg/ml an...
More data for this Ligand-Target Pair
Target Info
PDB
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KEGG
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Copy BDB DOI