Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetCathepsin L2(Homo sapiens (Human))
Astrazeneca

LigandBDBM31972(Dipeptidyl nitrile inhibitor, 5)Copy SMILESCopy InChI

Affinity DataIC50:  398nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
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TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
Astrazeneca

LigandBDBM31972(Dipeptidyl nitrile inhibitor, 5)Copy SMILESCopy InChI

Affinity DataIC50:  501nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCathepsin S(Homo sapiens (Human))
Astrazeneca

LigandBDBM31972(Dipeptidyl nitrile inhibitor, 5)Copy SMILESCopy InChI

Affinity DataIC50:  2.00E+3nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCathepsin K(Homo sapiens (Human))
Astrazeneca

LigandBDBM31972(Dipeptidyl nitrile inhibitor, 5)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetCathepsin B(Homo sapiens (Human))
Astrazeneca

LigandBDBM31972(Dipeptidyl nitrile inhibitor, 5)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI