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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
11
hits in this display
Target
Histamine H3 receptor
(Homo sapiens (Human))
Meiji Seika Kaisha
Curated by
ChEMBL
Ligand
BDBM50326286
((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
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Affinity Data
Ki: 18nM
Assay Description:
Displacement of [3H]-(R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Histamine H1 receptor
(Homo sapiens (Human))
Meiji Seika Kaisha
Curated by
ChEMBL
Ligand
BDBM50326286
((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
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Affinity Data
Ki: 48nM
Assay Description:
Binding affinity to human histamine H1 receptor
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Histamine H3 receptor
(Homo sapiens (Human))
Meiji Seika Kaisha
Curated by
ChEMBL
Ligand
BDBM50326286
((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 180nM
Assay Description:
Displacement of [3H]-(R)-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells by liquid scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histamine H4 receptor
(Homo sapiens (Human))
Meiji Seika Kaisha
Curated by
ChEMBL
Ligand
BDBM50326286
((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
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Copy InChI
Affinity Data
Ki: 310nM
Assay Description:
Binding affinity to human histamine H4 receptor
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histamine H2 receptor
(Homo sapiens (Human))
Meiji Seika Kaisha
Curated by
ChEMBL
Ligand
BDBM50326286
((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
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Affinity Data
Ki: >1.00E+4nM
Assay Description:
Binding affinity to human histamine H2 receptor
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Meiji Seika Kaisha
Curated by
ChEMBL
Ligand
BDBM50326286
((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
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Affinity Data
IC50: 9.50E+3nM
Assay Description:
Inhibition of CYP2D6
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
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Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
Details
Article
PubMed
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Target
Cytochrome P450 2C19
(Homo sapiens (Human))
Meiji Seika Kaisha
Curated by
ChEMBL
Ligand
BDBM50326286
((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
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Affinity Data
IC50: 1.20E+4nM
Assay Description:
Inhibition of CYP2C19
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
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Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Meiji Seika Kaisha
Curated by
ChEMBL
Ligand
BDBM50326286
((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
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Affinity Data
IC50: 1.70E+4nM
Assay Description:
Inhibition of CYP3A4
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Cytochrome P450 1A2
(Homo sapiens (Human))
Meiji Seika Kaisha
Curated by
ChEMBL
Ligand
BDBM50326286
((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
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Affinity Data
IC50: >9.40E+4nM
Assay Description:
Inhibition of CYP1A2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histamine H3 receptor
(Homo sapiens (Human))
Meiji Seika Kaisha
Curated by
ChEMBL
Ligand
BDBM50326286
((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 38nM
Assay Description:
Agonist activity at human histamine H3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Histamine H3 receptor
(Homo sapiens (Human))
Meiji Seika Kaisha
Curated by
ChEMBL
Ligand
BDBM50326286
((R)-4-(1-(1H-Imidazol-4-yl)-2-(4-(trifluoromethyl)...)
Copy SMILES
Copy InChI
Affinity Data
EC50: 74nM
Assay Description:
Agonist activity at human histamine H3 receptor expressed in CHO cells assessed as [35S]GTPgammaS binding
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI