Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 54 hits in this display
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Ki: 19nMAssay Description:Inhibition of human HDAC9 using (Boc-Lys(trifluoroacetyl)-AMC) as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Ki: 36nMAssay Description:Inhibition of human HDAC7 using (Boc-Lys(trifluoroacetyl)-AMC) as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Ki: 80nMAssay Description:Inhibition of human HDAC5 using (Boc-Lys(trifluoroacetyl)-AMC) as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Ki: 126nMAssay Description:Inhibition of human HDAC4 using (Boc-Lys(trifluoroacetyl)-AMC) as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Ki: 2.00E+3nMAssay Description:Inhibition of human HDAC6 using p53 residues 379-382 (RHKKAc) as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Ki: 4.00E+3nMAssay Description:Inhibition of human HDAC8 using p53 residues 379-382 (RHKAcKAc) as substrate as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Ki: >1.90E+4nMAssay Description:Inhibition of human HDAC2 using p53 (379 to 382 residues) (RHKKAc) as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Ki: >1.90E+4nMAssay Description:Inhibition of human HDAC11 using (Boc-Lys(trifluoroacetyl)-AMC) as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Ki: >2.30E+4nMAssay Description:Inhibition of human HDAC1 using p53 (379 to 382 residues) (RHKKAc) as substrate measured after 2 hrs by cheng-Prusoff analysisMore data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
Ki: >4.30E+4nMAssay Description:Inhibition of human HDAC3/NcoR2 using p53 residues 379-382 (RHKKAc) as substrate measured after 2 hrs by Cheng-Prusoff analysisMore data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
IC50: 32.4nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
IC50: 49nMAssay Description:Inhibition of HDAC9 (unknown origin) using fluorogenic HDAC class 2a as substrate measured after 1 to 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
IC50: 65.7nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
IC50: 153nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
IC50: 213nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
IC50: 300nMAssay Description:Inhibition of recombinant human HDAC4 using Boc-Lys(trifluoroacetyl)-AMC as substrate by homogeneous fluorescence release assayMore data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
IC50: 354nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
IC50: 376nMAssay Description:The inhibitory activity of panobinostat dissolved in DMSO and that of the HP-β-CD panobinostat adduct (prepared as described in Example 1) were ...More data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
IC50: >1.00E+4nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
IC50: >1.00E+4nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
IC50: >1.00E+4nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
IC50: >1.00E+4nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
IC50: >1.00E+4nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
IC50: >1.00E+4nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
IC50: >1.00E+4nMAssay Description: I. Compound handling: Testing compounds were dissolved in 100% DMSO to a specific concentration. The serial dilution was conducted by epMotion 5070 ...More data for this Ligand-Target Pair
BDBM50446481(CHEMBL3110004 | US10011611, TMP269 | US10722597, C...)
IC50: >4.30E+4nMAssay Description:Inhibition of human recombinant full length HDAC3-NCoR2 using Lys_Ac_AMC as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
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