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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
hits in this display
Target
Histone deacetylase 6
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM504845
(N-({3- fluoro-4-[5- (trifluoro- methyl)- 1,2,4-oxa...)
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Affinity Data
IC50: 33nM
Assay Description:
HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
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Target
Histone deacetylase 5
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM504845
(N-({3- fluoro-4-[5- (trifluoro- methyl)- 1,2,4-oxa...)
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Affinity Data
IC50: 140nM
Assay Description:
HDAC5 reagents: N-terminal GST tagged HDAC5 was purchased from BPS Bioscience [catalog #50045]. Assays were performed with buffer containing 20 mM HE...
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Histone deacetylase 1
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM504845
(N-({3- fluoro-4-[5- (trifluoro- methyl)- 1,2,4-oxa...)
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Copy InChI
Affinity Data
IC50: 1.60E+3nM
Assay Description:
HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI
Target
Histone deacetylase 8
(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Ligand
BDBM504845
(N-({3- fluoro-4-[5- (trifluoro- methyl)- 1,2,4-oxa...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.50E+4nM
Assay Description:
HDAC8 reagents: HDAC8 was purchased from Enzo Life Sciences [catalog #BML-SE145]. Assays were performed with buffer containing 20 mM HEPES, pH 8.0 [B...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
US Patent
Copy BDB DOI