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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
198
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 0.0600nM
Assay Description:
In vitro binding affinity towards dopamine transporter in rat striatal membranes by [3H]GBR-12395 displacement.
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.150nM
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.430nM
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.620nM
More data for this Ligand-Target Pair
Target Info
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.880nM
Assay Description:
Inhibitory constant towards reuptake of [125I]-12 from dopamine transporter in rat striatal membranes
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1nM
More data for this Ligand-Target Pair
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.40nM
More data for this Ligand-Target Pair
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 1.43nM
More data for this Ligand-Target Pair
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.42nM
Assay Description:
Displacement of [125I]IPT from DAT overexpressed in LLC-PK1 cell membrane by competitive binding assay
More data for this Ligand-Target Pair
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.70nM ΔG°: -44.7kJ/mole
pH: 7.4 T: 2°C
Assay Description:
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.70nM
Assay Description:
Binding affinity against Dopamine transporter using [125]RTI-55
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.70nM
Assay Description:
Affinity at rat dopamine transporter using [125I]-RTI-55 displacement.
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.70nM
Assay Description:
Binding affinity for dopamine transporter (DAT)
More data for this Ligand-Target Pair
Target Info
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ChEBI
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Copy BDB DOI
Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.70nM
Assay Description:
Binding affinity of the compound towards dopamine transporter (DAT)
More data for this Ligand-Target Pair
Target Info
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ChEBI
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PubMed
Copy BDB DOI
Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.70nM
Assay Description:
Binding affinity of the compound towards dopmine transporter(DAT) by using [125I]-RTI-55 radioligand
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.70nM
Assay Description:
Binding affinity for dopamine transporter
More data for this Ligand-Target Pair
Target Info
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KEGG
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ChEBI
CHEMBL
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Article
PubMed
Copy BDB DOI
Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.70nM
Assay Description:
Binding affinity against dopamine transporter labelled with [125I]- RTI-55 in rat.
More data for this Ligand-Target Pair
Target Info
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PubMed
Copy BDB DOI
Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.70nM
Assay Description:
Displacement of [125I]RTI55 from DAT in rat brain synaptosomes
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.70nM
Assay Description:
Binding affinity at dopamine transporter in rat brain by [3H]WIN-35428 displacement.
More data for this Ligand-Target Pair
Target Info
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ChEBI
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Article
PubMed
Copy BDB DOI
Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.80nM
More data for this Ligand-Target Pair
Target Info
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PubMed
Copy BDB DOI
Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.30nM
Assay Description:
Inhibition of [3H]-dopamine uptake via rat dopamine receptor.
More data for this Ligand-Target Pair
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.30nM
More data for this Ligand-Target Pair
Target Info
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4.70nM
Assay Description:
Displacement of [3H]-WIN35428 from human DAT expressed in HEK cell membrane assessed as inhibition constant by radioligand binding assay
More data for this Ligand-Target Pair
Target Info
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 5nM
More data for this Ligand-Target Pair
Target Info
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ChEBI
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PubMed
Copy BDB DOI
Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 5.07nM
Assay Description:
Inhibition of [3H]dopamine reuptake at dopamine transporter
More data for this Ligand-Target Pair
Target Info
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 8.60nM
Assay Description:
Inhibition of [3H]WIN 35428 binding to rat striatum DAT
More data for this Ligand-Target Pair
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 8.70nM
Assay Description:
DAT: This protocol was designed to measure inhibition of uptake by the human dopamine transporter. The reagents were human DAT (HEK293F) cells, GBR 1...
More data for this Ligand-Target Pair
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US Patent
Copy BDB DOI
Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 8.80nM
Assay Description:
Displacement of [3H]-WIN35428 from human DAT expressed in HEK293 cells measured after 30 mins
More data for this Ligand-Target Pair
Target Info
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 8.80nM
Assay Description:
Displacement of [3H]-WIN35428 from human DAT expressed in HEK293 cells measured after 30 mins
More data for this Ligand-Target Pair
Target Info
NCI pathway
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KEGG
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 10nM
Assay Description:
Inhibitory constant towards reuptake of [125I]-13 from dopamine transporter in rat striatal membranes
More data for this Ligand-Target Pair
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 10.2nM
Assay Description:
Displacement of [3H]WIN-from DAT in rat striatum
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 10.6nM
Assay Description:
Inhibition of [3H]dopamine uptake in DAT in rat striatum
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 10.6nM
Assay Description:
Inhibition of rat brain dopamine transporter as accumulation of [3H]-DA
More data for this Ligand-Target Pair
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 11nM
Assay Description:
Inhibition of DAT-mediated [3H]DA uptake in rat striatum
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 11.9nM
Assay Description:
Binding affinity against dopamine transporter was determined by the displacement of [3H]WIN-35428 radioligand in rat brain
More data for this Ligand-Target Pair
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: 12nM
Assay Description:
Compound was evaluated for its ability to displace [3H]WIN-35428 binding in rat caudate-putamen
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 12nM
Assay Description:
Binding affinity to dopamine transporter (DAT) using [3H]WIN-35428 as a radioligand
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 12nM
Assay Description:
Binding affinity Sprague-Dawley rats using [3H]WIN-35428 ligand
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
Ki: 12nM
Assay Description:
Binding affinity at dopamine transporter from rat caudate-putamen tissue by [3H]-WIN- 35428 displacement.
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Target
Sodium-dependent dopamine transporter
(MOUSE)
University Of Missouri
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 12nM
Assay Description:
Displacement of [3H]RTI-121 from mouse DAT in striatal membranes
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
Ki: 12nM
Assay Description:
Affinity for rat dopamine transporter using [3H]WIN-35428 displacement.
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
Ki: 12nM
Assay Description:
Displacement of [3H]WIN-35428 from dopamine transporter of rat caudate putamen tissue
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
Ki: 12nM
Assay Description:
Binding affinity at Dopamine transporter by displacing [3H]WIN-35428 from rat caudate putamen
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: 14nM
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: 15nM
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 16.2nM
Assay Description:
Inhibition of DAT in rat striatum assessed as [3H]dopamine accumulation
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Target
Histamine H1 receptor
(RAT)
Novo Industri
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: 18nM
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 18nM
Assay Description:
Inhibition of [3H]DA uptake at DAT in rat brain striatal synaptosomes by liquid scintillation spectrophotometry
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 22nM
Assay Description:
Displacement of [3H]WIN35428 from DAT after 1.5 hrs by scintillation counting
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 24nM
Assay Description:
Binding affinity against Serotonin transporter in male Sprague-Dawley rats using [3H]paroxetine ligand
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Target
Sodium-dependent serotonin transporter
(MOUSE)
University Of Missouri
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 24nM
Assay Description:
Displacement of [3H]paroxetine from mouse SERT in whole brain membrane
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 30.6nM
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Ki: 31nM
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: 52.8nM
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: 53nM
Assay Description:
In vitro binding affinity towards serotonin transporter in rat cerebral cortical homogenates by [3H]paroxetine displacement.
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: 73nM
Assay Description:
Inhibition of [3H]-5-HT uptake at the rat serotonin transporter.
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: 73.2nM
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Target
Transporter
(Rattus norvegicus)
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: 79nM
Assay Description:
Inhibition of [3H]-norepinephrine uptake at the rat norepinephrine transporter.
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Target
Norepinephrine transporter
(RAT)
Nih
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: 79.2nM
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: 91nM
Assay Description:
Inhibition of SERT-mediated [3H]5HT uptake in rat cerebral cortex
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 91.1nM
Assay Description:
Inhibition of rat brain Serotonin transporter as accumulation of [3H]-5-HT
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 91.1nM
Assay Description:
Inhibition of [3H]5HT uptake in SERT in rat cerebral cortex
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Target
Transporter
(Rattus norvegicus)
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: 102nM
Assay Description:
Inhibition of rat brain Norepinephrin transporter as accumulation of [3H]-NE
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Target
Transporter
(Rattus norvegicus)
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: 102nM
Assay Description:
Inhibition of NET-mediated [3H]NE uptake in rat cerebral cortex
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Target
Transporter
(Rattus norvegicus)
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 102nM
Assay Description:
Inhibition of [3H]NE uptake in NET in rat cerebral cortex
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 105nM
Assay Description:
Binding affinity at Serotonin transporter using [3H]citalopram as radioligand from rat brain
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 105nM
Assay Description:
Binding affinity against serotonin transporter by displacement of [3H]citalopram in rat brain
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Target
D(3) dopamine receptor
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: 109nM
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Target
Sigma non-opioid intracellular receptor 1
(RAT)
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 116nM
Assay Description:
Binding affinity of Sigma opioid receptor type 2 in rat liver membranes using [3H]DTG ligand
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 126nM
Assay Description:
Displacement of [125I]RTI55 from SERT in rat brain synaptosomes
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Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 126nM
Assay Description:
Binding affinity for serotonin transporter (SERT) using [125I]-RTI-55
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 126nM
Assay Description:
Binding affinity towards rat serotonin transporter (SERT)
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
Ki: 126nM
Assay Description:
Affinity at rat serotonin transporter using [125I]-RTI-55 displacement.
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 126nM
Assay Description:
Binding affinity against Serotonin transporter (SERT) labelled with [125I]-RTI-55 in rat.
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
Ki: 126nM
Assay Description:
Binding affinity for serotonin transporter (SERT)
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Copy BDB DOI
Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
Ki: 130nM ΔG°: -36.5kJ/mole
pH: 7.4 T: 2°C
Assay Description:
The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...
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Copy BDB DOI
Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
Ki: 130nM
Assay Description:
Binding affinity against serotonin transporter using [125]RTI-55
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Copy BDB DOI
Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
Ki: 130nM
Assay Description:
Binding affinity for serotonin transporter
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Target
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human))
Mayo Foundation
US Patent
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 138nM
Assay Description:
NET: This protocol was designed to measure inhibition of uptake by the human norepinephrine transporter. The reagents were human NET (HEK293F) cells,...
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 161nM
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Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 168nM
Assay Description:
SERT: This protocol was designed to measure inhibition of uptake by the human serotonin transporter. The reagents were human SERT (HEK293F) cells, fl...
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Copy BDB DOI
Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
Ki: 170nM
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Target
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 189nM
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
Ki: 198nM
Assay Description:
Inhibition of SERT in rat cerebral cortex assessed as [3H]serotonin accumulation
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Target
D(2) dopamine receptor
(Rattus norvegicus (rat))
Novo Industri
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 270nM
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Target
Sigma non-opioid intracellular receptor 1
(Homo sapiens (Human))
Nida-Irp
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 318nM
Assay Description:
Binding affinity against Sigma receptor type 1 was determined by the displacement of [3H]pentazocine radioligand
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Target
Norepinephrine transporter
(RAT)
Nih
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 440nM
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Target
Transporter
(Rattus norvegicus (rat))
University Of New Orleans
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 496nM
Assay Description:
Displacement of [3H]nisoxetine from NET in Sprague-Dawley rat brain cortex membranes after 1 hr
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Target
D(2) dopamine receptor
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 737nM
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Target
D(1A) dopamine receptor
(RAT)
Novo Industri
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: 1.00E+3nM
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Target
Transporter
(Rattus norvegicus)
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 1.27E+3nM
Assay Description:
Binding affinity at norepinephrine transporter using [3H]nisoxetine as radioligand from rat brain
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Target
Transporter
(Rattus norvegicus)
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 1.27E+3nM
Assay Description:
Displacement of [3H]nisoxetine from rat brain norepinephrine transporter
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Transporter
(Rattus norvegicus)
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 1.27E+3nM
Assay Description:
The compound was tested for binding affinity nisoxatine ligand
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Target
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat))
Novo Industri
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: 3.50E+3nM
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Target
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat))
Novo Industri
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: 3.60E+3nM
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Target
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: 4.68E+3nM
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Target
Alpha-2C adrenergic receptor
(RAT)
Novo Industri
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PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: 7.00E+3nM
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Target
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat))
Novo Industri
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: 8.00E+3nM
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Target
Norepinephrine transporter
(RAT)
Nih
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 2C
(Rattus norvegicus (Rat))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: >1.00E+4nM
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Target
D(1A) dopamine receptor
(Homo sapiens (Human))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: >1.00E+4nM
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Target
Gamma-aminobutyric acid receptor subunit alpha-1
(Rattus norvegicus (Rat))
Novo Industri
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: >1.00E+4nM
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Target
Beta-1 adrenergic receptor
(Rattus norvegicus (Rat))
Novo Industri
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: >1.00E+4nM
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Target
Muscarinic acetylcholine receptor M2
(RAT)
Novo Industri
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PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: >1.00E+4nM
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Target
5-hydroxytryptamine receptor 3A
(Mus musculus (house mouse))
Sri International
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Ki: >1.00E+4nM
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Target
Transporter
(Rattus norvegicus)
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
Ki: >2.00E+4nM
Assay Description:
In vitro binding affinity towards Norepinephrine transporter rat cerebral cortical homogenates by [3H]nisoxetine displacement.
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 0.430nM
Assay Description:
Displacement of [125I]RTI-55 dopamine transporter binding in rat striatal membrane
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 0.710nM
Assay Description:
Displacement of [125I]RTI-55 from recombinant human DAT expressed in CHOK1 cells after 3 hrs by scintillation counting method
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 1nM
Assay Description:
Inhibition of [125I]RTI-55 cocaine binding to the dopamine transporter.
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Target
Sigma non-opioid intracellular receptor 1
(Homo sapiens (Human))
Nida-Irp
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 1nM
Assay Description:
The compound was tested for affinity towards sigma-3 receptor
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 1.80nM
Assay Description:
Reuptake inhibition was determined at the dopamine transporter labeled with radioligand [3H]-dopamine in nonstandard conditions on brain membranes ob...
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
IC50: 2nM
Assay Description:
Inhibition of dopamine transporter (unknown origin)
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 2.30nM
Assay Description:
Inhibition of Dopamine uptake in male Sprague-Dawley rats using [3H]DA ligand
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 2.60nM
Assay Description:
Binding affinity was determined at the dopamine transporter labeled with radioligand [125 I] RTI-55 in nonstandard conditions
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 3nM
Assay Description:
Inhibition of dopamine uptake at dopamine transporter.
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
IC50: 3.70nM
Assay Description:
Binding affinity was determined at the dopamine transporter labeled with radioligand [125 I] RTI-55
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
IC50: 3.70nM
Assay Description:
Binding affinity for rat Dopamine transporter.
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 4nM
Assay Description:
Inhibition of [3H]GBR-12935 binding to the dopamine transporter.
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 4.30nM
Assay Description:
Compound was tested for its ability to inhibit the uptake of [3H]-dopamine in DAT (dopamine transporter system) expressing cell line
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
IC50: 4.30nM
Assay Description:
Compound was tested for its ability to inhibit the neurotransmitter dopamine-DA reuptake system using [3H]dopamine as radioligand
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
IC50: 4.30nM
Assay Description:
Inhibition of dopamine DA reuptake
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
IC50: 4.30nM
Assay Description:
The inhibition of reuptake of the compound against dopamine transporter
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Target
Sodium-dependent dopamine transporter
(MOUSE)
University Of Missouri
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 5nM
Assay Description:
Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 5.5nM
Assay Description:
Binding against Dopamine transporter using radioligand as [3H]GBR 12935
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 6nM
Assay Description:
Binding affinity at dopamine transporter from rat striatal membrane tissue by [3H]-CFT displacement.
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
IC50: 6.63nM
Assay Description:
Inhibition of uptake from dopamine transporter in rat striatum using [3H]DA as radioligand
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
IC50: 7.20nM
Assay Description:
Inhibition of human dopamine transporter
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 7.30nM
Assay Description:
Inhibition of [3H]DA reuptake in rat caudate homogenate.
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 7.30nM
Assay Description:
Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-dopamine on synaptosomes obtained from rat caudate.
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
IC50: 7.30nM
Assay Description:
Reuptake inhibition of [3H]-labeled dopamine (DA) in rat.
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 10.6nM
Assay Description:
Inhibition of [3H]WIN-35428 binding to dopamine transporter of rat striatum
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
IC50: 10.6nM
Assay Description:
Inhibition of binding of 3[H] WIN-35 428 to Dopamine transporter (DAT) of rat striatum.
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
IC50: 10.6nM
Assay Description:
Binding affinity towards dopamine transporter in rat striatum using [3H]WIN-35 428 as radioligand
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
IC50: 10.6nM
Assay Description:
Binding affinity at the dopamine transporter in rast striatum by [3H]WIN-35428 displacement.
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
IC50: 10.6nM
Assay Description:
In vitro binding affinity at dopamine transporter in rat striatum by [3H]WIN-35428 displacement.
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 10.6nM
Assay Description:
Displacement of [3H]WIN35428 from DAT in Sprague-Dawley rat brain homogenates after 1 hr by scintillation counting
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
IC50: 10.6nM
Assay Description:
Inhibition of [3H]-WIN- 35,428 binding to rat brain dopamine transporter
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 11nM
Assay Description:
Inhibition of binding of [3H]WIN-35 428 to (DAT) dopamine transporter in rat striatum
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 14nM
Assay Description:
In vitro inhibition of [3H]-WIN- 35, 428 binding to dopamine transporter on rat striatal membranes.
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
IC50: 14nM
Assay Description:
Inhibitory activity against dopamine transporter (DAT) labeled with [3H]-WIN- 35,428 in rat brain striatal membrane.
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
IC50: 14nM
Assay Description:
Displacement of [3H]Win35428 from human recombinant DAT over-expressed in CHOK1 cells
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
IC50: 14.2nM
Assay Description:
Inhibition of rat brain Dopamine transporter uptake as [3H]-DA accumulation
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 19.3nM
Assay Description:
IC50 value of the compound was evaluated using [3H]-WIN- 35,428 (radioligand) on Dopamine transporter in rat striatum.
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 21.1nM
Assay Description:
Displacement of [3H]WIN 35428 from DAT in Sprague-Dawley rat striatum
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 24nM
Assay Description:
Inhibition of [3H]BTCP binding to the dopamine transporter.
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 26nM
Assay Description:
Affinity of the compound was evaluated using [3H]-DA (radioligand) on Cloned human Dopamine transporter expressed in HEK cells
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 33nM
Assay Description:
Inhibition of [3H]GBR-12935 binding to the dopamine transporter.
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 36nM
Assay Description:
Inhibition of [3H]cocaine binding to the dopamine transporter.
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 40nM
Assay Description:
Inhibition of re-uptake of [3H]-DA at human DAT expressed in HEK293 cells by liquid scintillation counting
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Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 43nM
Assay Description:
Inhibition of [3H]-5-dopamine reuptake in human DAT expressed in HEK293 cells by microbeta liquid scintillation counting method
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Target
Sigma non-opioid intracellular receptor 1
(Homo sapiens (Human))
Nida-Irp
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 43nM
Assay Description:
Sigma receptor binding was determined by labeling with radioligand [3H]-(+)-pentazocine on frozen membranes obtained from frozen guinea pig brain
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 43nM
Assay Description:
Affinity of the compound was evaluated using [3H]-WIN- 35,428 (radioligand) on Cloned human Dopamine transporter expressed in HEK cells
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 70nM
Assay Description:
Compound was tested for its ability to inhibit the neurotransmitter serotonin-5-HT reuptake system using [3H]5-HT as radioligand
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 73nM
Assay Description:
Reuptake inhibition of [3H]-5-HT (5-HT) in rat.
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 73nM
Assay Description:
Inhibitory activity against [3H]- 5-hydroxytryptamine reuptake in whole rat brain minus cerebellum
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Target
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat))
Research Biochemicals International
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 73nM
Assay Description:
Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-5-HT on synaptosomes obtained from whole rat brain minus cerebellum.
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 73nM
Assay Description:
Inhibition of [3H]5-HT reuptake at rat serotonin transporter
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Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 73nM
Assay Description:
The inhibition of reuptake of the compound against Serotonin transporter (5-HT)
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Sodium-dependent noradrenaline transporter
(Homo sapiens (Human))
Mayo Foundation
US Patent
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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IC50: 79nM
Assay Description:
Compound was tested for the inhibition of norepinephrine (NE) reuptake
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Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 82nM
Assay Description:
Binding affinity at serotonin transporter from rat brain striatal membrane by [3H]-citalopram displacement.
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 82nM
Assay Description:
In vitro inhibition of [3H]-citalopram binding to serotonin transporter on rat striatal membranes.
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 86.6nM
Assay Description:
Inhibitory activity against serotonin transporter (SERT) labeled with [3H]-citalopram in rat brain striatal membrane.
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 87nM
Assay Description:
IC50 value of the compound was evaluated using [3H]-citalopram (radioligand) on serotonin transporter in rat striatum.
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 101nM
Assay Description:
Inhibition of rat brain Serotonin transporter uptake as [3H]-5-HT accumulation
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Target
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human))
Mayo Foundation
US Patent
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 110nM
Assay Description:
Inhibition of [3H]-5-norepinephrine reuptake in human NET expressed in HEK293 cells by microbeta liquid scintillation counting method
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Target
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human))
Mayo Foundation
US Patent
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 110nM
Assay Description:
Inhibition of re-uptake of [3H]-NE at human NET expressed in HEK293 cells by liquid scintillation counting
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Target
Transporter
(Rattus norvegicus)
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 114nM
Assay Description:
Inhibition of rat brain Norepinephrin transporter as accumulation of [3H]-NE
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 126nM
Assay Description:
Binding affinity for rat 5-hydroxytryptamine transporter.
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 126nM
Assay Description:
Binding affinity was determined at the Serotonin transporter labeled with radioligand [125 I] RTI-55
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 132nM
Assay Description:
Inhibition of [3H]citalopram binding to serotonin transporter of rat cerebral cortex
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 132nM
Assay Description:
Binding affinity towards serotonin transporter in rat striatum using [3H]citalopram as radioligand
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 132nM
Assay Description:
Inhibition of binding of [3H]- citalopram to Serotonin transporter (SERT) of rat cerebral cortex.
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 132nM
Assay Description:
Binding affinity at serotonin transporter in rat striatum by [3H]citalopram displacement.
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 132nM
Assay Description:
In vitro binding affinity at serotonin transporter in rat striatum by [3H]- citalopram displacement.
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Target
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
IC50: 132nM
Assay Description:
Inhibition of binding of [3H]citalopram to (SERT) serotonin transporter in rat striatum
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Sodium-dependent serotonin transporter
(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 132nM
Assay Description:
Displacement of [3H]citalopram from SERT in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting
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Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
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Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 190nM
Assay Description:
Inhibition of DA reuptake at human DAT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 190nM
Assay Description:
Inhibition of human DAT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay
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Target
Sodium-dependent dopamine transporter
(Homo sapiens (Human))
University of Toronto
Curated by
PDSP K
i
Database
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 190nM
Assay Description:
Inhibition of human DAT expressed in HEK293 cells assessed as inhibition of dopamine reuptake after 30 mins by fluorescence assay
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Target
Voltage-dependent L-type calcium channel subunit alpha-1C
(Cavia porcellus)
Jagiellonian University
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 320nM
Assay Description:
Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes
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Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Mayo Foundation
US Patent
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 470nM
Assay Description:
HERG: The pre- and post-compound hERG current was evoked by a single voltage pulse consisting of a 20 s period holding at −70 mV, a 160 ms step...
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Target
Transporter
(Rattus norvegicus)
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 496nM
Assay Description:
Inhibition of binding of [3H]nisoxetine to (NET) norepinephrine transporter in rat striatum
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Target
Transporter
(Rattus norvegicus)
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 496nM
Assay Description:
Inhibition of binding of [3H]- nisoxatine to Norepinephrine transporter (NET) of rat cerebral cortex.
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Target
Transporter
(Rattus norvegicus)
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 496nM
Assay Description:
Affinity at norepinephrine transporter (NET) in rat striatum, using [3H]- nisoxatine as radioligand
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Transporter
(Rattus norvegicus)
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 496nM
Assay Description:
Binding affinity at the norepinephrine transporter in rat striatum by [3H]nisoxetine displacement.
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Transporter
(Rattus norvegicus)
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 496nM
Assay Description:
Binding affinity towards norepinephrine transporter in rat striatum using [3H]nisoxetine as radioligand
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Transporter
(Rattus norvegicus)
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
IC50: 496nM
Assay Description:
Inhibition of [3H]nisoxetine binding to norepinephrine transporter of rat cerebral cortex
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Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 741nM
Assay Description:
Affinity of the compound was evaluated using [3H]-citalopram (radioligand) on human serotonin transporter expressed in HEK cells
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Target
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human))
Mayo Foundation
US Patent
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 1.46E+3nM
Assay Description:
Inhibition of norepinephrine reuptake at human NET expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay
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Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 1.46E+3nM
Assay Description:
Inhibition of human NET expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay
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Target
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human))
Mayo Foundation
US Patent
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 1.46E+3nM
Assay Description:
Inhibition of human NET expressed in HEK293 cells assessed as inhibition of noradrenaline reuptake after 30 mins by fluorescence assay
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Target
Kappa-type opioid receptor
(Homo sapiens (Human))
Universities Of Lille
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 2.14E+3nM
Assay Description:
Binding affinity against opioid receptor kappa 1 by using [3H]U-69593 as radioligand
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Target
Mu-type opioid receptor
(Homo sapiens (Human))
Universities Of Lille
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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IC50: 3.53E+3nM
Assay Description:
Binding affinity against mu opioid receptor using [3H]DAMGO
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Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 3.84E+3nM
Assay Description:
Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay
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Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
IC50: 3.84E+3nM
Assay Description:
Inhibition of human SERT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assay
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Target
Sodium-dependent serotonin transporter
(Homo sapiens (Human))
Niddk
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Copy SMILES
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Affinity Data
IC50: 3.84E+3nM
Assay Description:
Inhibition of human SERT expressed in HEK293 cells assessed as inhibition of serotonin reuptake after 30 mins by fluorescence assay
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Target
Arachidonate 15-lipoxygenase
(Pseudomonas aeruginosa)
University of California Santa Cruz
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: 8.00E+3nM
T: 2°C
Assay Description:
Briefly, 3 uL of enzyme (approximately 20 nM LoxA, final concentration) or buffer (no-enzyme control) was dispensed into 1536-well Greiner black clea...
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Delta-type opioid receptor
(Homo sapiens (Human))
Universities Of Lille
Curated by
ChEMBL
Ligand
BDBM22165
(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Binding affinity against delta opiate receptor using [3H]DPDPE
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