Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 198 hits in this display   

TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  0.0600nMAssay Description:In vitro binding affinity towards dopamine transporter in rat striatal membranes by [3H]GBR-12395 displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  0.150nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  0.430nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  0.620nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  0.880nMAssay Description:Inhibitory constant towards reuptake of [125I]-12 from dopamine transporter in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  1.40nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  1.43nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  2.42nMAssay Description:Displacement of [125I]IPT from DAT overexpressed in LLC-PK1 cell membrane by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.70nM ΔG°:  -44.7kJ/molepH: 7.4 T: 2°CAssay Description:The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity against Dopamine transporter using [125]RTI-55More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.70nMAssay Description:Affinity at rat dopamine transporter using [125I]-RTI-55 displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity for dopamine transporter (DAT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity of the compound towards dopamine transporter (DAT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity of the compound towards dopmine transporter(DAT) by using [125I]-RTI-55 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity for dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity against dopamine transporter labelled with [125I]- RTI-55 in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [125I]RTI55 from DAT in rat brain synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity at dopamine transporter in rat brain by [3H]WIN-35428 displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.80nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  4.30nMAssay Description:Inhibition of [3H]-dopamine uptake via rat dopamine receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  4.30nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]-WIN35428 from human DAT expressed in HEK cell membrane assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  5.07nMAssay Description:Inhibition of [3H]dopamine reuptake at dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  8.60nMAssay Description:Inhibition of [3H]WIN 35428 binding to rat striatum DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  8.70nMAssay Description:DAT: This protocol was designed to measure inhibition of uptake by the human dopamine transporter. The reagents were human DAT (HEK293F) cells, GBR 1...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  8.80nMAssay Description:Displacement of [3H]-WIN35428 from human DAT expressed in HEK293 cells measured after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  8.80nMAssay Description:Displacement of [3H]-WIN35428 from human DAT expressed in HEK293 cells measured after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  10nMAssay Description:Inhibitory constant towards reuptake of [125I]-13 from dopamine transporter in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  10.2nMAssay Description:Displacement of [3H]WIN-from DAT in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  10.6nMAssay Description:Inhibition of [3H]dopamine uptake in DAT in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  10.6nMAssay Description:Inhibition of rat brain dopamine transporter as accumulation of [3H]-DAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  11nMAssay Description:Inhibition of DAT-mediated [3H]DA uptake in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  11.9nMAssay Description:Binding affinity against dopamine transporter was determined by the displacement of [3H]WIN-35428 radioligand in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  12nMAssay Description:Compound was evaluated for its ability to displace [3H]WIN-35428 binding in rat caudate-putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  12nMAssay Description:Binding affinity to dopamine transporter (DAT) using [3H]WIN-35428 as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  12nMAssay Description:Binding affinity Sprague-Dawley rats using [3H]WIN-35428 ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  12nMAssay Description:Binding affinity at dopamine transporter from rat caudate-putamen tissue by [3H]-WIN- 35428 displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(MOUSE)
University Of Missouri

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]RTI-121 from mouse DAT in striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  12nMAssay Description:Affinity for rat dopamine transporter using [3H]WIN-35428 displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]WIN-35428 from dopamine transporter of rat caudate putamen tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  12nMAssay Description:Binding affinity at Dopamine transporter by displacing [3H]WIN-35428 from rat caudate putamenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  14nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  15nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  16.2nMAssay Description:Inhibition of DAT in rat striatum assessed as [3H]dopamine accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Novo Industri

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  18nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  18nMAssay Description:Inhibition of [3H]DA uptake at DAT in rat brain striatal synaptosomes by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]WIN35428 from DAT after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  24nMAssay Description:Binding affinity against Serotonin transporter in male Sprague-Dawley rats using [3H]paroxetine ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(MOUSE)
University Of Missouri

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]paroxetine from mouse SERT in whole brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  30.6nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  31nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  52.8nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  53nMAssay Description:In vitro binding affinity towards serotonin transporter in rat cerebral cortical homogenates by [3H]paroxetine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  73nMAssay Description:Inhibition of [3H]-5-HT uptake at the rat serotonin transporter.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  73.2nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  79nMAssay Description:Inhibition of [3H]-norepinephrine uptake at the rat norepinephrine transporter.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  79.2nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  91nMAssay Description:Inhibition of SERT-mediated [3H]5HT uptake in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  91.1nMAssay Description:Inhibition of rat brain Serotonin transporter as accumulation of [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  91.1nMAssay Description:Inhibition of [3H]5HT uptake in SERT in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  102nMAssay Description:Inhibition of rat brain Norepinephrin transporter as accumulation of [3H]-NEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  102nMAssay Description:Inhibition of NET-mediated [3H]NE uptake in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  102nMAssay Description:Inhibition of [3H]NE uptake in NET in rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  105nMAssay Description:Binding affinity at Serotonin transporter using [3H]citalopram as radioligand from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  105nMAssay Description:Binding affinity against serotonin transporter by displacement of [3H]citalopram in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  109nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  116nMAssay Description:Binding affinity of Sigma opioid receptor type 2 in rat liver membranes using [3H]DTG ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  126nMAssay Description:Displacement of [125I]RTI55 from SERT in rat brain synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  126nMAssay Description:Binding affinity for serotonin transporter (SERT) using [125I]-RTI-55More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  126nMAssay Description:Binding affinity towards rat serotonin transporter (SERT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  126nMAssay Description:Affinity at rat serotonin transporter using [125I]-RTI-55 displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  126nMAssay Description:Binding affinity against Serotonin transporter (SERT) labelled with [125I]-RTI-55 in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  126nMAssay Description:Binding affinity for serotonin transporter (SERT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  130nM ΔG°:  -36.5kJ/molepH: 7.4 T: 2°CAssay Description:The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  130nMAssay Description:Binding affinity against serotonin transporter using [125]RTI-55More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  130nMAssay Description:Binding affinity for serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Foundation

US Patent
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  138nMAssay Description:NET: This protocol was designed to measure inhibition of uptake by the human norepinephrine transporter. The reagents were human NET (HEK293F) cells,...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  161nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  168nMAssay Description:SERT: This protocol was designed to measure inhibition of uptake by the human serotonin transporter. The reagents were human SERT (HEK293F) cells, fl...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  170nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  189nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  198nMAssay Description:Inhibition of SERT in rat cerebral cortex assessed as [3H]serotonin accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Novo Industri

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  270nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Nida-Irp

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  318nMAssay Description:Binding affinity against Sigma receptor type 1 was determined by the displacement of [3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  440nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus (rat))
University Of New Orleans

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  496nMAssay Description:Displacement of [3H]nisoxetine from NET in Sprague-Dawley rat brain cortex membranes after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  737nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(1A) dopamine receptor(RAT)
Novo Industri

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  1.27E+3nMAssay Description:Binding affinity at norepinephrine transporter using [3H]nisoxetine as radioligand from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  1.27E+3nMAssay Description:Displacement of [3H]nisoxetine from rat brain norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  1.27E+3nMAssay Description:The compound was tested for binding affinity nisoxatine ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Novo Industri

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.50E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Novo Industri

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.60E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  4.68E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAlpha-2C adrenergic receptor(RAT)
Novo Industri

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  7.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
Novo Industri

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  8.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rattus norvegicus (Rat))
Novo Industri

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Rattus norvegicus (Rat))
Novo Industri

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Novo Industri

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(Mus musculus (house mouse))
Sri International

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTransporter(Rattus norvegicus)
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi: >2.00E+4nMAssay Description:In vitro binding affinity towards Norepinephrine transporter rat cerebral cortical homogenates by [3H]nisoxetine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  0.430nMAssay Description:Displacement of [125I]RTI-55 dopamine transporter binding in rat striatal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  0.710nMAssay Description:Displacement of [125I]RTI-55 from recombinant human DAT expressed in CHOK1 cells after 3 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  1nMAssay Description:Inhibition of [125I]RTI-55 cocaine binding to the dopamine transporter.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Nida-Irp

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  1nMAssay Description:The compound was tested for affinity towards sigma-3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  1.80nMAssay Description:Reuptake inhibition was determined at the dopamine transporter labeled with radioligand [3H]-dopamine in nonstandard conditions on brain membranes ob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  2nMAssay Description:Inhibition of dopamine transporter (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of Dopamine uptake in male Sprague-Dawley rats using [3H]DA ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  2.60nMAssay Description:Binding affinity was determined at the dopamine transporter labeled with radioligand [125 I] RTI-55 in nonstandard conditionsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  3nMAssay Description:Inhibition of dopamine uptake at dopamine transporter.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  3.70nMAssay Description:Binding affinity was determined at the dopamine transporter labeled with radioligand [125 I] RTI-55More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  3.70nMAssay Description:Binding affinity for rat Dopamine transporter.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  4nMAssay Description:Inhibition of [3H]GBR-12935 binding to the dopamine transporter.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  4.30nMAssay Description:Compound was tested for its ability to inhibit the uptake of [3H]-dopamine in DAT (dopamine transporter system) expressing cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  4.30nMAssay Description:Compound was tested for its ability to inhibit the neurotransmitter dopamine-DA reuptake system using [3H]dopamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of dopamine DA reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  4.30nMAssay Description:The inhibition of reuptake of the compound against dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(MOUSE)
University Of Missouri

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  5.5nMAssay Description:Binding against Dopamine transporter using radioligand as [3H]GBR 12935More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  6nMAssay Description:Binding affinity at dopamine transporter from rat striatal membrane tissue by [3H]-CFT displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  6.63nMAssay Description:Inhibition of uptake from dopamine transporter in rat striatum using [3H]DA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of human dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of [3H]DA reuptake in rat caudate homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  7.30nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-dopamine on synaptosomes obtained from rat caudate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  7.30nMAssay Description:Reuptake inhibition of [3H]-labeled dopamine (DA) in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  10.6nMAssay Description:Inhibition of [3H]WIN-35428 binding to dopamine transporter of rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  10.6nMAssay Description:Inhibition of binding of 3[H] WIN-35 428 to Dopamine transporter (DAT) of rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  10.6nMAssay Description:Binding affinity towards dopamine transporter in rat striatum using [3H]WIN-35 428 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  10.6nMAssay Description:Binding affinity at the dopamine transporter in rast striatum by [3H]WIN-35428 displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  10.6nMAssay Description:In vitro binding affinity at dopamine transporter in rat striatum by [3H]WIN-35428 displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  10.6nMAssay Description:Displacement of [3H]WIN35428 from DAT in Sprague-Dawley rat brain homogenates after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  10.6nMAssay Description:Inhibition of [3H]-WIN- 35,428 binding to rat brain dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  11nMAssay Description:Inhibition of binding of [3H]WIN-35 428 to (DAT) dopamine transporter in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibition of [3H]-WIN- 35, 428 binding to dopamine transporter on rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against dopamine transporter (DAT) labeled with [3H]-WIN- 35,428 in rat brain striatal membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  14nMAssay Description:Displacement of [3H]Win35428 from human recombinant DAT over-expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  14.2nMAssay Description:Inhibition of rat brain Dopamine transporter uptake as [3H]-DA accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  19.3nMAssay Description:IC50 value of the compound was evaluated using [3H]-WIN- 35,428 (radioligand) on Dopamine transporter in rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  21.1nMAssay Description:Displacement of [3H]WIN 35428 from DAT in Sprague-Dawley rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  24nMAssay Description:Inhibition of [3H]BTCP binding to the dopamine transporter.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  26nMAssay Description:Affinity of the compound was evaluated using [3H]-DA (radioligand) on Cloned human Dopamine transporter expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  33nMAssay Description:Inhibition of [3H]GBR-12935 binding to the dopamine transporter.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  36nMAssay Description:Inhibition of [3H]cocaine binding to the dopamine transporter.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  40nMAssay Description:Inhibition of re-uptake of [3H]-DA at human DAT expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  43nMAssay Description:Inhibition of [3H]-5-dopamine reuptake in human DAT expressed in HEK293 cells by microbeta liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Nida-Irp

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  43nMAssay Description:Sigma receptor binding was determined by labeling with radioligand [3H]-(+)-pentazocine on frozen membranes obtained from frozen guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  43nMAssay Description:Affinity of the compound was evaluated using [3H]-WIN- 35,428 (radioligand) on Cloned human Dopamine transporter expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  70nMAssay Description:Compound was tested for its ability to inhibit the neurotransmitter serotonin-5-HT reuptake system using [3H]5-HT as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  73nMAssay Description:Reuptake inhibition of [3H]-5-HT (5-HT) in rat.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  73nMAssay Description:Inhibitory activity against [3H]- 5-hydroxytryptamine reuptake in whole rat brain minus cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  73nMAssay Description:Reuptake inhibition at the dopamine transporter labeled with radioligand [3H]-5-HT on synaptosomes obtained from whole rat brain minus cerebellum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  73nMAssay Description:Inhibition of [3H]5-HT reuptake at rat serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  73nMAssay Description:The inhibition of reuptake of the compound against Serotonin transporter (5-HT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Foundation

US Patent
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  79nMAssay Description:Compound was tested for the inhibition of norepinephrine (NE) reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  82nMAssay Description:Binding affinity at serotonin transporter from rat brain striatal membrane by [3H]-citalopram displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  82nMAssay Description:In vitro inhibition of [3H]-citalopram binding to serotonin transporter on rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  86.6nMAssay Description:Inhibitory activity against serotonin transporter (SERT) labeled with [3H]-citalopram in rat brain striatal membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  87nMAssay Description:IC50 value of the compound was evaluated using [3H]-citalopram (radioligand) on serotonin transporter in rat striatum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  101nMAssay Description:Inhibition of rat brain Serotonin transporter uptake as [3H]-5-HT accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Foundation

US Patent
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  110nMAssay Description:Inhibition of [3H]-5-norepinephrine reuptake in human NET expressed in HEK293 cells by microbeta liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Foundation

US Patent
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  110nMAssay Description:Inhibition of re-uptake of [3H]-NE at human NET expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  114nMAssay Description:Inhibition of rat brain Norepinephrin transporter as accumulation of [3H]-NEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  126nMAssay Description:Binding affinity for rat 5-hydroxytryptamine transporter.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  126nMAssay Description:Binding affinity was determined at the Serotonin transporter labeled with radioligand [125 I] RTI-55More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  132nMAssay Description:Inhibition of [3H]citalopram binding to serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  132nMAssay Description:Binding affinity towards serotonin transporter in rat striatum using [3H]citalopram as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  132nMAssay Description:Inhibition of binding of [3H]- citalopram to Serotonin transporter (SERT) of rat cerebral cortex.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  132nMAssay Description:Binding affinity at serotonin transporter in rat striatum by [3H]citalopram displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  132nMAssay Description:In vitro binding affinity at serotonin transporter in rat striatum by [3H]- citalopram displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  132nMAssay Description:Inhibition of binding of [3H]citalopram to (SERT) serotonin transporter in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  132nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  190nMAssay Description:Inhibition of DA reuptake at human DAT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human DAT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human DAT expressed in HEK293 cells assessed as inhibition of dopamine reuptake after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Cavia porcellus)
Jagiellonian University

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  320nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Mayo Foundation

US Patent
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  470nMAssay Description:HERG: The pre- and post-compound hERG current was evoked by a single voltage pulse consisting of a 20 s period holding at −70 mV, a 160 ms step...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTransporter(Rattus norvegicus)
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  496nMAssay Description:Inhibition of binding of [3H]nisoxetine to (NET) norepinephrine transporter in rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  496nMAssay Description:Inhibition of binding of [3H]- nisoxatine to Norepinephrine transporter (NET) of rat cerebral cortex.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  496nMAssay Description:Affinity at norepinephrine transporter (NET) in rat striatum, using [3H]- nisoxatine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  496nMAssay Description:Binding affinity at the norepinephrine transporter in rat striatum by [3H]nisoxetine displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  496nMAssay Description:Binding affinity towards norepinephrine transporter in rat striatum using [3H]nisoxetine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus)
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  496nMAssay Description:Inhibition of [3H]nisoxetine binding to norepinephrine transporter of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  741nMAssay Description:Affinity of the compound was evaluated using [3H]-citalopram (radioligand) on human serotonin transporter expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Foundation

US Patent
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  1.46E+3nMAssay Description:Inhibition of norepinephrine reuptake at human NET expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  1.46E+3nMAssay Description:Inhibition of human NET expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Mayo Foundation

US Patent
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  1.46E+3nMAssay Description:Inhibition of human NET expressed in HEK293 cells assessed as inhibition of noradrenaline reuptake after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  2.14E+3nMAssay Description:Binding affinity against opioid receptor kappa 1 by using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  3.53E+3nMAssay Description:Binding affinity against mu opioid receptor using [3H]DAMGOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  3.84E+3nMAssay Description:Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  3.84E+3nMAssay Description:Inhibition of human SERT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Niddk

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  3.84E+3nMAssay Description:Inhibition of human SERT expressed in HEK293 cells assessed as inhibition of serotonin reuptake after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 15-lipoxygenase(Pseudomonas aeruginosa)
University of California Santa Cruz

LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50:  8.00E+3nMT: 2°CAssay Description:Briefly, 3 uL of enzyme (approximately 20 nM LoxA, final concentration) or buffer (no-enzyme control) was dispensed into 1536-well Greiner black clea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Universities Of Lille

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity against delta opiate receptor using [3H]DPDPEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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