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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 17 hits in this display   

TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataKi:  42nMAssay Description:Inhibition of N-terminally GST- tagged human DLK catalytic domain (1 to 520 amino acids) using N-terminally HIS-tagged MKK4 K131M as substrate incuba...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 12(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50:  536nMAssay Description:Inhibition of Dox inducible human DLK transfected in HEK293 cells assessed as reduction in JNK phosphorylation incubated for 5.5 hrs measured by Hoec...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50:  1.04E+3nMAssay Description:Inhibition of JNK1 (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of JNK3 (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of JNK2 (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MKK7 (unknown origin) using KFMMTPpYVVTR substrate incubated for 1 hr measured by MpTPpYV probe-based fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of MKK4 (unknown origin) using KFMMTPpYVVTR substrate incubated for 1 hr measured by MpTPpYV probe-based fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MLK3 (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MLK1 (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 10(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MLK2 (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50:  5.70E+4nMAssay Description:Inhibition of CSF1R (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50:  3.22E+5nMAssay Description:Inhibition of Flt3 (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50:  4.64E+5nMAssay Description:Inhibition of TrkA (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50:  5.34E+5nMAssay Description:Inhibition of Kit (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50:  6.82E+5nMAssay Description:Inhibition of GSK3beta (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50:  1.01E+6nMAssay Description:Inhibition of Src (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50128294(CHEMBL3629013)
Affinity DataIC50:  1.19E+6nMAssay Description:Inhibition of TrkB (unknown origin) by FRET methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed