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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetArginase-1(Homo sapiens (Human))
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509015(CHEMBL4594157)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM50509017(CHEMBL4578964)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM290401((3R,4S)-3-amino-4-(3-boronopropyl)-1-(pyrrolidin-2...)
Affinity DataIC50:  125nMAssay Description:Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetArginase-1(Homo sapiens (Human))
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM290401((3R,4S)-3-amino-4-(3-boronopropyl)-1-(pyrrolidin-2...)
Affinity DataIC50: <250nMpH: 7.4 T: 2°CAssay Description:Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM290401((3R,4S)-3-amino-4-(3-boronopropyl)-1-(pyrrolidin-2...)
Affinity DataIC50:  625nMpH: 7.4 T: 2°CAssay Description:Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM290401((3R,4S)-3-amino-4-(3-boronopropyl)-1-(pyrrolidin-2...)
Affinity DataIC50:  625nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetArginase-1(Homo sapiens (Human))
New England Discovery Partners

Curated by ChEMBL
LigandPNGBDBM290401((3R,4S)-3-amino-4-(3-boronopropyl)-1-(pyrrolidin-2...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetArginase-2, mitochondrial(Homo sapiens (Human))
Mars

US Patent
LigandPNGBDBM290401((3R,4S)-3-amino-4-(3-boronopropyl)-1-(pyrrolidin-2...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent