Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)
Found 45 hits in this display
BDBM11542((1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxyadamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
IC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as bufuralol 1'-hydroxylation preincubated for 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
IC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as midazolam 1'-hydroxylation preincubated for 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
IC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as midazolam 1'-hydroxylation after 3 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
IC50: >5.00E+4nMAssay Description:Inhibition of CYP2E1 in human liver microsomes assessed as chlorzoxazone 6-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
IC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes assessed as bufuralol 1'-hydroxylation after 3 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
IC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes assessed as (S)-mephenytoin 4'-hydroxylation after 3 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
IC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
IC50: >5.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes assessed as paclitaxel 6alpha-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
IC50: >5.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as bupropion hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
IC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes assessed as (S)-mephenytoin 4'-hydroxylation preincubated for 15 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
IC50: >5.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes assessed as bupropion hydroxylation preincubated for 15 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
IC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes assessed as testosterone 6beta-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
IC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes assessed as phenacetin O-deethylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
IC50: >5.00E+4nMAssay Description:Inhibition of CYP2A6 in human liver microsomes assessed as coumarin 7-hydroxylation after 3 mins by LC-MS/MS analysis in presence of NADPHMore data for this Ligand-Target Pair
BDBM11542((1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxyadamantan-1...)
BDBM11542((1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxyadamantan-1...)
BDBM11542((1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxyadamantan-1...)
BDBM11542((1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxyadamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)
BDBM50225074((1S,3S,5S)-2-[(S)-2-amino-2-(3-hydroxy-adamantan-1...)