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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM432403(N-((1R,3R,5S)-8-((1r,4R)-4- aminocyclohexane-1-car...)
Affinity DataIC50:  106nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM432492(N-(8-((1r,4r)-4-aminocyclohexane-1- carbonyl)-8-az...)
Affinity DataIC50: >1.00E+4nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM432402(N-((1R,3S,5S)-8-((1r,4R)-4- aminocyclohexane-1-car...)
Affinity DataIC50: >1.00E+4nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent